Heidi M. Schambra

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The mechanisms of action of tDCS for behavioral modification are not yet fully understood. However, one common observation is that its behavioral effects are most pronounced and long-lasting when tDCS is paired with endogenous, training-induced brain activity (1). In humans, training produces modality-specific neural network activation and(More)
Transcranial Direct Current Stimulation (tDCS) is a method of non-invasive brain stimulation that has been frequently used in experimental and clinical pain studies. However, the molecular mechanisms underlying tDCS-mediated pain control, and most important its placebo component, are not completely established. In this pilot study, we investigated in vivo(More)
Reversible posterior leukoencephalopathy syndrome (RPLS) is characterized radiographically by magnetic resonance imaging as white matter hyperintensities, which reflect cerebral edema. These changes are typically restricted to the parietal and occipital lobes, and are usually quite symmetric. We report a case of asymmetric RPLS involving only one frontal(More)
Human and animal studies show significant delays in neurobehavioral development in offspring after prolonged prenatal exposure to moderate and high ethanol doses resulting in high blood alcohol concentration (BECs). However, none have investigated the effects of lower ethanol doses given acutely during specific developmental time periods. Here, we sought to(More)
BACKGROUND Reducing inhibitory neurotransmission with pharmacological agents is a potential approach for augmenting plasticity after stroke. Previous work in healthy subjects showed diminished intracortical inhibition after administration of theophylline. OBJECTIVE We assessed the effect of single-dose theophylline on intracortical and interhemispheric(More)
About half of patients survive intracerebral hemorrhage (ICH), but most are left with significant disability. Rehabilitation after ICH is the mainstay of treatment to reduce impairment, improve independence in activities, and return patients to meaningful participation in the community. The authors discuss the neuroplastic mechanisms underlying recovery in(More)
Rehabilitation of hemineglect is vexingly inadequate. Beyond its direct detrimental effect on visual-spatial function, hemineglect interferes with rehabilitation of cognitive and motor function. 1 Interventions targeting this condition include relearning appropriate visuospatial scanning behaviors through practice and cuing, engaging the attentional system(More)
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