Heidi Janssen

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UNLABELLED In all, 19-22% of the adult Danish population suffer from chronic pain - most frequently in the musculoskeletal system. Different pain management strategies depending on pain mechanism (neuropathic/nociceptive) make diagnosing the pain condition especially important. OBJECTIVES To investigate whether a validated, self-administered questionnaire(More)
To the Editor: We agree with Swedberg et al.,1 whose Sounding Board article is now published in the Journal, regarding the role and responsibilities of the data monitoring committee. We also agree that the data monitoring committee should be allowed to act independently during the progress of a trial. The committee’s role is to provide continuous safety(More)
In contrast to vitamin K antagonists, no routine coagulation monitoring is required in patients taking non-vitamin-K oral anticoagulants (NOACs). However, dosing must take into account factors such as patient age, renal function, and accompanying haemorrhagic risk. There has been considerable debate about when laboratory measurement might be appropriate and(More)
Despite the availability of a number of different classes of therapeutic agents with proven efficacy in heart failure, the clinical course of heart failure patients is characterized by a reduction in life expectancy, a progressive decline in health-related quality of life and functional status, as well as a high risk of hospitalization. New approaches are(More)
Recently, Shimada and Cannon reviewed in this journal the development of the proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors, a new therapeutic option for the treatment of familial hypercholesterolaemia; indeed, two new medicines, Repatha (active substance: evolocumab) and Praluent (active substance: alirocumab), have now received a(More)
New European Union (EU) pharmacovigilance legislation, effective from July 2012, introduced new concepts and procedures to optimise the way medicines are regulated within the Union and provided new channels for public health interventions. Triggered by the EU legislation, the work done by the International Conference on Harmonisation (ICH) has provided a(More)
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