Heidi E. Kosiorek

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It remains challenging to produce decisive vaccines against MUC1, a tumor-associated antigen widely expressed by pancreas, breast and other tumors. Employing clinically relevant mouse models, we ruled out such causes as irreversible T-cell tolerance, inadequate avidity, and failure of T-cells to recognize aberrantly glycosylated tumor MUC1. Instead, every(More)
A cancer diagnosis requires significant information to facilitate health care decision making, understand management options, and health care system navigation. Patient knowledge deficit can decrease quality of life and health care compliance. Surveys were distributed to attendees of the Mayo Clinic “Living with and Surviving Cancer” patient symposium(More)
Myelofibrosis (MF) is a clonal Philadelphia negative myeloproliferative neoplasm that is associated with cytopenias, splenomegaly, a heterogeneous symptom profile, and decreased overall survival. 1 Accurate prognos-tication of MF is essential for clinical decision making, as survival estimates often tip the scales toward or away from consideration of(More)
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