Learn More
OBJECTIVE Major depressive disorder (MDD) is one of the most common psychiatric disorders, conferring considerable individual, family, and community burden. To date, treatments for MDD have been derived from the monoamine hypothesis, and there is a paucity of emerging antidepressants, especially with novel mechanisms of action and treatment targets.(More)
BACKGROUND N-acetyl cysteine (NAC) is a glutathione precursor that has been shown to have antidepressant efficacy in a placebo-controlled trial. The current study aimed to investigate the maintenance effects of NAC following eight weeks of open-label treatment for bipolar disorder. METHOD The efficacy of a double blind randomized placebo controlled trial(More)
238 The known pharmacokinetic profile of a medication does not always point to its therapeutic potential. Many treatments were discovered serendipitously as a consequence of careful clinical observation, often in the context of treatment of apparently unrelated conditions. Consequently, many widely-used therapies have current uses well removed from their(More)
  • 1