Heidi Cobb

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OBJECTIVE Major depressive disorder (MDD) is one of the most common psychiatric disorders, conferring considerable individual, family, and community burden. To date, treatments for MDD have been derived from the monoamine hypothesis, and there is a paucity of emerging antidepressants, especially with novel mechanisms of action and treatment targets.(More)
In this paper, we study the ability of a non-fluent aphasic patient, BN, to comprehend morphologically complex words when they appear in utterance contexts. We first establish that he is insensitive to the contextual appropriateness of both derived and inflected words. In a further experiment we show that he has no difficulty processing the stems of complex(More)
This study investigates the ability of an aphasic patient (DE) to process bound grammatical morphemes in normal sentential contexts. A word monitoring task examined the patient's sensitivity to the contextual appropriateness of derivational and inflectional suffixes. The results show that he is differentially sensitive to derivational and inflectional(More)
BACKGROUND N-acetyl cysteine (NAC) is a glutathione precursor that has been shown to have antidepressant efficacy in a placebo-controlled trial. The current study aimed to investigate the maintenance effects of NAC following eight weeks of open-label treatment for bipolar disorder. METHOD The efficacy of a double blind randomized placebo controlled trial(More)
238 The known pharmacokinetic profile of a medication does not always point to its therapeutic potential. Many treatments were discovered serendipitously as a consequence of careful clinical observation, often in the context of treatment of apparently unrelated conditions. Consequently, many widely-used therapies have current uses well removed from their(More)
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