Heidee Villanueva

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Current concepts concerning nicotine's CNS mechanism(s) of action suggest that this drug produces its effects via an interaction at nicotinic-cholinergic receptors (nAChRs) sensitive to acetylcholine. In vitro research further suggests that, following its initial agonist effect, this cholinergic drug may also induce a rapid desensitization of the nAChR(More)
The present study examined the effects of the neuroleptic pimozide on several measures of motor capacity and reinforcement efficacy in rats trained to respond according to a multiple random interval (RI) food reinforcement schedule (mean interreinforcement intervals of 10, 20, 40, 80, and 160 sec). Pimozide (0.125, 0.25, 0.5, and 1.0 mg/kg) produced a(More)
Our thinking about how nicotine might be inducing DS control of behavior has changed drastically in the past 25 years. Our first inclination was that nicotine was mimicking ACh at a variety of specific and select n-AChRs. Then several nicotine researchers suggested that nicotine might be acting via specific and select noncholinergic receptors. At present,(More)
A 19-year-old female with Systemic Lupus Erythematosus (SLE) presented with ischemia of her left hand following trauma. Medical therapy was initiated but failed to improve her symptoms, and revision amputation was ultimately performed. The patient's final diagnosis was digital ischemia due to secondary Raynaud's Phenomenon (RP). The authors discuss(More)
Sprague-Dawley rats were maintained on a daily regimen of nicotine, morphine or saline administration for 28 days. Following the discontinuation of the daily drug regimen, rats were given a choice of tap water or a saccharin-water solution. The rats previously receiving morphine drank significantly less saccharin-water solution than did the rats receiving(More)
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