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TRIM28 regulates RNA polymerase II promoter proximal pausing and pause release
TLDR
In vivo and in vitro mechanistic studies suggest that transcription-coupled phosphorylation regulates Pol II pause release by TRIM28, which is identified as a new factor that modulates Pol II pausing and transcriptional elongation at a large number of mammalian genes. Expand
Transcriptional elongation requires DNA break-induced signalling
TLDR
It is proposed that DDR signalling is required for effective Pol II pause release and transcriptional elongation through a novel mechanism involving TRIM28, DNA-PK and topoisomerase II. Expand
Gene regulation of mammalian long non-coding RNA
  • Heeyoun Bunch
  • Biology, Medicine
  • Molecular Genetics and Genomics
  • 1 February 2018
TLDR
In this review, the newly discovered transcription mechanisms, characteristics, and functions of lncRNA are discussed. Expand
TRIM28 as a novel transcriptional elongation factor
TLDR
Critical regulatory mechanisms of TRIM28 in transcriptional control and DNA repair that may illuminate the novel roles of this factor in pausing and elongation of Pol II are discussed. Expand
Type II DNA Topoisomerases Cause Spontaneous Double-Strand Breaks in Genomic DNA
TLDR
This review discusses spontaneously arising DSBs caused by the abortive catalysis of TOP2 and summarizes proteins involved in repairing stalled TOP2ccs and discusses the genotoxicity of the sex hormones. Expand
RNA polymerase II promoter-proximal pausing in mammalian long non-coding genes.
TLDR
The genomic study has shown that a significant number of long non-coding RNAs (lncRNAs, >1000 nucleotides) harbor RNA polymerase II (Pol II) engaged with the transcriptional start site, suggesting an important role of Pol II pausing for the transcription of mammalian lncRNA genes. Expand
Role of genome guardian proteins in transcriptional elongation
TLDR
In this review, recent findings of these DNA break‐ and repair‐associated enzymes in transcription and potential roles of transcriptional activation‐coupled DNA breaks are discussed. Expand
RNA polymerase II pausing and transcriptional regulation of the HSP70 expression.
  • Heeyoun Bunch
  • Biology, Medicine
  • European journal of cell biology
  • 1 December 2017
TLDR
Drosophila and human HSP70 genes serve as a bona fide model system to understand the mechanisms of Pol II pausing and pause release and are discussed in this review. Expand
Glyphosate influences cell proliferation in vitro
TLDR
The IARC classified glyphosate as a Class 2A ‘probable carcinogen’ to humans, however, since the International Agency for Research on Cancer (IARC) classification, it has not been classed as a carcinogen to humans. Expand
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