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Structural Determinants for the Selectivity of the Positive KCa3.1 Gating Modulator 5-Methylnaphtho[2,1-d]oxazol-2-amine (SKA-121).

• Brandon M. Brown, Heesung Shim, Miao Zhang, Vladimir Yarov-Yarovoy, Heike Wulff
• Molecular pharmacology
• 2017

Intermediate-conductance (KCa3.1) and small-conductance (KCa2) calcium-activated K+ channels are gated by calcium binding to calmodulin (CaM) molecules associated with the calmodulin-binding domain… (More)

Are there superagonists for calcium-activated potassium channels?

• Brandon M. Brown, Heesung Shim, Heike Wulff
• Channels
• 2017

Similar to GABAA receptor-channels the calciummediated gating of the small-conductance KCa2 and the intermediate-conductance KCa3.1 channels can be positively or negatively modulated by small… (More)

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