Heejung Park

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Human apurinic/apyrimidinic endonuclease 1 (APE1) is an essential protein for DNA base excision repair (BER) and redox regulation. The ability of cancer cells to recognize DNA damage and initiate DNA repair is an important mechanism for therapeutic resistance. Several recent studies have suggested that APE1 expression levels and/or subcellular dysregulation(More)
OBJECTIVE To investigate the associations between objective and subjective dimensions of adolescent sleep and C-reactive protein (CRP), a key biomarker of inflammation that predicts chronic health problems in adulthood, and whether the associations vary as a function of adolescents' age. METHODS A total of 315 adolescents (14.5-18.4 years) wore wrist(More)
GNAS mutations have been implicated in the development of fibrous dysplasia and multiple endocrinopathies of the Albright-McCune syndrome. To investigate the diagnostic utility of GNAS mutations in patients with fibrous dysplasia, we performed mutational analyses of histologically confirmed fibrous dysplasia and conducted a meta-analysis of the literature.(More)
PATIENT Male, 59 FINAL DIAGNOSIS: Xanthogranulomatous osteomyelitis Symptoms: Painful swelling in the wrist Medication: Drug history of antifulgal agents Clinical Procedure: Excisional biopsy Specialty: Radiology. OBJECTIVE Rare disease. BACKGROUND Xanthogranulomatous inflammation is a chronic inflammatory disease in which bone involvement is extremely(More)
People with central-field loss must use peripheral vision for reading. Previous studies have shown that reading performance in peripheral vision can improve with extensive practice on a trigram letter-recognition task. The present study compared training on this task with training on two other character-based tasks (lexical-decision and Rapid Serial Visual(More)
There are three formats for arranging English text for vertical reading-upright letters arranged vertically (marquee), and horizontal text rotated 90 degrees clockwise or counterclockwise. Previous research has shown that reading is slower for all three vertical formats than for horizontal text, with marquee being slowest (M. D. Byrne, 2002). It has been(More)
A 31-year-old Korean male presented with altered consciousness and severe headache. Brain MRI delineated focal leptomeningeal enhancement without any intracerebral lesions. Diagnosis was made based on a brain biopsy showing anaplastic large cell lymphoma (ALCL), immunohistochemical stains revealing positivity for anaplastic lymphoma kinase (ALK) and an(More)
It is increasingly evident that conditional gene expression in pigs is necessary to make transgenic models. In this study, we investigated conditional expression in porcine fetal fibroblasts using Cre-loxP recombination, a system that has had limited application in large animals to date. Transformed fibroblasts were reprogrammed in enucleated oocytes to(More)
BACKGROUND Epstein-Barr virus (EBV)-associated hemophagocytic lymphohistiocytosis (HLH), EBV-positive systemic T-cell lymphoproliferative disease (STLPD) of childhood, and chronic active EBV (CAEBV) infection may develop after primary EBV infection. This study reviewed the clinicopathological spectrum of EBV-associated T- and natural killer (NK)-cell LPD,(More)