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Tumor-homing poly-siRNA/glycol chitosan self-cross-linked nanoparticles for systemic siRNA delivery in cancer treatment.
The condensed version: Thiolated glycol chitosan can form stable nanoparticles with polymerized siRNAs through charge-charge interactions and self-cross-linking (see scheme). This poly-siRNA/glycol… Expand
The movement of self-assembled amphiphilic polymeric nanoparticles in the vitreous and retina after intravitreal injection.
- Heebeom Koo, Hyungwon Moon, +8 authors Hyuncheol Kim
- Materials Science, Medicine
- 1 April 2012
The purpose of this study is to determine the correlation between the distribution of nanoparticles in the vitreous and retina and their surface properties after intravitreal injection. For this… Expand
Self-assembled nanoparticles based on hyaluronic acid-ceramide (HA-CE) and Pluronic® for tumor-targeted delivery of docetaxel.
Hyaluronic acid-ceramide (HA-CE)-based self-assembled nanoparticles were developed for intravenous docetaxel (DCT) delivery. In this study, physicochemical properties, cellular uptake efficiency, and… Expand
Multifunctional nanoparticles for multimodal imaging and theragnosis.
- Dongeun Lee, Heebeom Koo, In-Cheol Sun, Ju Hee Ryu, K. Kim, I. C. Kwon
- Chemistry, Medicine
- Chemical Society reviews
- 12 March 2012
Nanomedicine is the biomedical application of nanoscale materials for diagnosis and therapy of disease. Recent advances in nanotechnology and biotechnology have contributed to the development of… Expand
Polyethylene glycol-conjugated hyaluronic acid-ceramide self-assembled nanoparticles for targeted delivery of doxorubicin.
Polyethylene glycol (PEG)-conjugated hyaluronic acid-ceramide (HACE) was synthesized for the preparation of doxorubicin (DOX)-loaded HACE-PEG-based nanoparticles, 160 nm in mean diameter with a… Expand
In vivo tumor diagnosis and photodynamic therapy via tumoral pH-responsive polymeric micelles.
- Heebeom Koo, Hye-jung Lee, +7 authors S. Jeong
- Medicine, Chemistry
- Chemical communications
- 28 July 2010
We report protoporphyrin IX (PpIX) encapsulated pH-responsive micelles for cancer treatment. This system showed pH-responsive micellization/demicellization transition at tumoral acidic pH and enabled… Expand
Bioorthogonal copper-free click chemistry in vivo for tumor-targeted delivery of nanoparticles.
Visualization of the degradation of a disulfide polymer, linear poly(ethylenimine sulfide), for gene delivery.
Polyethylenimine (PEI) shows high transfection efficiency and cytoxicity due to its high amine density. The new disulfide cationic polymer, linear poly(ethylenimine sulfide) (l-PEIS), was synthesized… Expand
Photosensitizer-Conjugated Human Serum Albumin Nanoparticles for Effective Photodynamic Therapy
Photodynamic therapy (PDT) is an emerging theranostic modality for various cancers and diseases. The focus of this study was the development of tumor-targeting albumin nanoparticles containing… Expand
Enhanced drug-loading and therapeutic efficacy of hydrotropic oligomer-conjugated glycol chitosan nanoparticles for tumor-targeted paclitaxel delivery.
- Heebeom Koo, Kyung Hyun Min, +6 authors K. Kim
- Chemistry, Medicine
- Journal of controlled release : official journal…
- 28 December 2013
Enhanced drug-loading and therapeutic efficacies are highly essential properties for nanoparticles as tumor-targeting drug carriers. Herein, we developed the glycol chitosan nanoparticles with… Expand