Hee Sung Park

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Metformin use has recently been observed to decrease both the rate and mortality of breast cancer. Our study was aim to determine whether metformin use is associated with survival in diabetic breast cancer patients by breast cancer subtype and systemic treatment. Data from the Asan Medical Center Breast Cancer Database from 1997 to 2007 were analyzed. The(More)
Exposure of cells to ultraviolet B (UVB) radiation can induce production of free radicals and reactive oxygen species (ROS), which damage cellular components. In addition, these agents can stimulate the expression of matrix metalloproteinase (MMP) and decrease collagen synthesis in human skin cells. In this study, we examined the anti-photoaging effects of(More)
We report a smart mesoporous silica nanoparticle (MSN) with a pore surface designed to undergo charge conversion in intracellular endosomal condition. The surface of mesopores in the silica nanoparticles was engineered to have pH-hydrolyzable citraconic amide. Solid-state nuclear magnetic resonance (NMR), Fourier-transform infrared (FT-IR) spectroscopy, and(More)
Hot water-soluble crude polysaccharide (HCAP-0) that was obtained from the fruits of Capsicum annuum showed potent anti-complementary activity. The activity was unchanged by pronase digestion, but decreased by periodate oxidation. The HCAP-0 was fractionated by DEAE ion-exchange chromatography to give two major fractions, HCAP-II and III. These two(More)
Tumor hypoxia is associated with treatment resistance, cell proliferation, and metastatic potential, all of which contribute to a poor prognosis. Resveratrol [RES (trans-3,4',5-trihydroxystilbene)], a naturally occurring polyphenol, is enriched in grapes and red wine. This study investigated whether the resveratrol analog HS-1793 modulates the hypoxic(More)
This paper looks at empty arguments in Korean, and the constraints that can be used in recovering their meaning, or referent. We look at scrambling to provide insights into the process by which empty arguments can be recovered, and provide a computational algorithm based on local and global information that takes advantage of the semantic restrictions(More)
This paper aims to introduce a facility operation modeling and simulation mainly based on a discrete event system modeling scheme. Facilities have become so much complex that its operational status cannot be estimated by simple calculations. A facility can consist of a lot of unit process and a lot of transportation between consecutive processes, which may(More)
The aim of this study was to compare the effects of triamcinolone (TA)- and saline-soaked biodegradable nasal dressing on subjective symptoms, wound healing and improvement of olfactory dysfunction in patients with chronic rhinosinusitis with nasal polyposis (CRSwNP) after undergoing endoscopic sinus surgery (ESS). The study was a prospective, randomized,(More)
The exact regulatory mechanisms of carboxyl-terminal modulator protein (CTMP) and its downstream pathways in cancer have been controversial and are not completely understood. Here, we report a new mechanism of regulation of Akt serine/threonine kinase, one of the most important dysregulated signals in head and neck squamous cell carcinoma (HNSCC) by the(More)
OBJECTIVE There are many conflicting reports about the clinical implications of BRAF(V600E) in papillary thyroid cancer (PTC). We investigated the associations between the extent of BRAF(V600E) alleles and both clinico-pathological features and recurrence of PTC. MATERIALS AND METHODS Carcinoma tissues from 60 patients with PTC were genotyped for(More)