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Basal cell carcinomas (BCC), which are the most common form of skin malignancy, are invariably associated with the deregulation of the Sonic Hedgehog (Shh) signalling pathway. As such, BCC represent a unique model for the study of interactions of the Shh pathway with other genes and pathways. We constructed a tissue microarray (TMA) of 75 paired BCC and(More)
BACKGROUND Low tumour expression levels of thymidylate synthase (TS), dihydropyrimidine dehydrogenase (DPD) and thymidine phosphorylase (TP) have been linked with improved outcome for colorectal cancer (CRC) patients treated with 5-fluorouracil (5-FU). It is unclear whether this occurs because such tumours have better prognosis or they are more sensitive to(More)
The conventional P300-based character spelling BCI system consists of a character presentation paradigm and a classification system. In this paper, we propose modifications to both in order to increase the word typing speed and accuracy. In the paradigm part, we have modified the T9 (Text on Nine keys) interface which is similar to the keypad of mobile(More)
This was a prospective study of a new objective method which quantitatively analyses the upper airways in patients with obstructive sleep apnoea (OSA). Video-nasopharyngoscopic examinations of the upper airways of 45 patients were carried out with an endoscopic calibrator. Images of the upper airway during quiet respiration and Mueller's manoeuvre in erect(More)
A tissue microarray analysis of 22 proteins in gastrointestinal stromal tumours (GIST), followed by an unsupervised, hierarchical monothetic cluster statistical analysis of the results, allowed us to detect a vascular endothelial growth factor (VEGF) protein overexpression signature discriminator of prognosis in GIST, and discover novel VEGF-A DNA variants(More)
Lately, neuromodulation of the brain is considered one of the promising applications of ultrasound technology in which low-intensity focused ultrasound (LIFU) is used noninvasively to excite or inhibit neuronal activity. In LIFU, one of critical barriers in the propagation of ultrasound wave is the skull, which is known to be highly anisotropic(More)
Ultrasound is a promising neural stimulation modality, but an incomplete understanding of its range and mechanism of effect limits its therapeutic application. We investigated the modulation of spontaneous hippocampal spike activity by ultrasound at a lower acoustic intensity and longer time scale than has been previously attempted, hypothesizing that(More)
2021 Background: Low levels of the 5-Fluorouracil (5-FU) metabolic enzymes, thymidylate synthase (TS), dihydropyrimdine dehydrogenase (DPD) and thymidine phosphorylase (TP) are linked to improved survival in colorectal cancer (CRC) patients receiving 5-FU chemotherapy. However, whether they are prognostic (related to tumor biology) or predictive (drug(More)
Human pose estimation in real-time is a challenging problem in computer vision. In this paper, we present a novel approach to recover a 3D human pose in real-time from a single depth human silhouette using Principal Direction Analysis (PDA) on each recognized body part. In our work, the human body parts are first recognized from a depth human body(More)
P300 is an event related potential of the brain in response to oddball events. Brain Computer Interface (BCI) utilizing P300 is known as a P300 BCI system. A conventional P300 BCI system for character spelling is composed of a paradigm that displays flashing characters and a classification scheme which identifies target characters. To type a word a user has(More)
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