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Emergence and global spread of epidemic healthcare-associated Clostridium difficile
TLDR
This analysis identifies key genetic changes linked to the rapid transcontinental dissemination of epidemic C. difficile 027/BI/NAP1 and highlights the routes by which it spreads through the global healthcare system. Expand
Human Immunodeficiency Virus Protein Tat Induces Synapse Loss via a Reversible Process That Is Distinct from Cell Death
TLDR
The results suggest that the impaired network function and decreased neuronal survival produced by Tat involve distinct mechanisms and that pharmacologic targets, such as LRP, might prove useful in restoring function in HAD patients. Expand
Small Submucosal Tumors of the Stomach: Differentiation of Gastric Schwannoma from Gastrointestinal Stromal Tumor with CT
TLDR
Although small GSs and GISTs show similar imaging findings, GSs more frequently show an exophytic or mixed growth pattern, homogeneous enhancement pattern, perilesional LNs and grow slower than GISTS. Expand
Cellular and genetic diversity in the progression of in situ human breast carcinomas to an invasive phenotype.
TLDR
In several tumors, stem cell-like and more-differentiated cancer cell populations were genetically distinct, leading to question the validity of a simple differentiation hierarchy-based cancer stem cell model. Expand
Long non-coding RNA HOTAIR is associated with human cervical cancer progression
TLDR
Findings indicate that HOTAIR may represent a novel biomarker for predicting recurrence and prognosis and serve as a promising therapeutic target in cervical cancer. Expand
Activation of Cannabinoid Type 2 Receptors Inhibits HIV-1 Envelope Glycoprotein gp120-Induced Synapse Loss
TLDR
Results indicate that cannabinoids prevent the impairment of network function produced by gp120 and, thus, might have therapeutic potential in HAD. Expand
Inhibition of endoplasmic reticulum stress alleviates lipopolysaccharide-induced lung inflammation through modulation of NF-κB/HIF-1α signaling pathway
TLDR
It is suggested that inhibition of ER stress ameliorates LPS-induced lung inflammation through modulation of NF-κB/IκB and HIF-1α signaling pathway. Expand
PIK3CA mutations in in situ and invasive breast carcinomas.
TLDR
The results suggest that mutation of PIK3CA is an early event in breast cancer that is more likely to play a role in breast tumor initiation than in invasive progression, although a potential role for exon 9 mutations in the progression of a subset of DCIS cases cannot be excluded. Expand
The long noncoding RNA HOXA11 antisense induces tumor progression and stemness maintenance in cervical cancer
TLDR
HXA11-AS overexpression correlated with poor survival in patients with cervical cancer and may be a pivotal target for exploring novel cervical cancer therapeutics. Expand
Lithium Increases Synapse Formation between Hippocampal Neurons by Depleting Phosphoinositides
TLDR
Investigation of the effects of lithium on the number of synaptic connections between hippocampal neurons in culture showed that new synapses formed as a result of depletion of phosphatidylinositol-4-phosphate rather than a build-up of polyphosphoinositides or changes in the activity of phospholipase C, protein kinase C-3-kinase, or phosph atidyl inositol -3-Kinase. Expand
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