Hedvig Perlmann

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Immunoglobulin E has been associated with severe malaria suggesting a regulatory role for interleukin (IL)-4 and/or IgE in the pathogenesis of severe malaria. We have investigated possible associations between polymorphisms in the IL-4 repeat region (intron 3) and promoter regions (IL-4 +33CT and - 590CT) in Ghanaian children with severe malaria. There was(More)
BACKGROUND The IL4-590 gene polymorphism has been shown to be associated with elevated levels of anti-Plasmodium falciparum IgG antibodies and parasite intensity in the malaria protected Fulani of West Africa. This study aimed to investigate the possible impact of IL4-590C/T polymorphism on anti-P. falciparum IgG subclasses and IgE antibodies levels and the(More)
The occurrence and distribution of distinct receptors for three C3 fragments on purified human blood lymphocytes were studied by rosette formation. Indicator cells were bovine, chicken, or sheep erythrocytes (E) bearing up to 100,000 molecules of human C3b (EC3b) without antibody. EC3b was converted to C3bi-bearing-E (EC3bi) with purified C3b inactivator(More)
The capacity of a DNA probe containing cloned repetitive sequences from Plasmodium falciparum to identify malaria-infected blood samples was tested with a spot hybridisation assay. Parasitaemia levels of 0.001% could be detected in 50 microliters blood from patients. The probe correctly diagnosed P falciparum infection in patients from different continents(More)
Human blood lymphocytes were fractionated on glass bead columns charged with sheep erythrocyte (Es) membranes-bearing human C3b (7,000-10,000 molecules/Es). In the passaged cells the proportion of C receptor lymphocytes was strongly reduced, in parallel with the capacity to lyse chicken erythrocytes (Ec) in the presence of IgG-rabbit anti-Ec antibody. In(More)
Pf 155, a protein of the human malaria parasite Plasmodium falciparum, is strongly immunogenic in humans and is believed to be a prime candidate for the preparation of a vaccine. Human monoclonal antibodies to Pf 155 were obtained by cloning B cells that had been prepared from an immune donor and transformed with Epstein-Barr virus. When examined by(More)
Whereas the capacity of IgG antibodies to induce a cytolytic activity in certain lymphocytes (K cells) is well established (1), that of IgM antibodies is considered to be of doubtful significance (2, 3). In fact, it has been shown that IgM antibodies may inhibit the IgG-dependent reaction (4). However, Lamon et al. (5, 6) have now provided evidence that IgM(More)
Malaria is one of the most widely spread human diseases today and constitutes a major public health problem for a large part of the world's population. The dramatic rise of the disease since the mid-1960's has resulted in renewed attempts to find ways of controlling the disease by immunological measures. Although the immune response to the malaria parasites(More)
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