Hedia Chagraoui

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The cyclin-dependent kinase inhibitor p21(Waf-1/Cip-1) is expressed at high level during megakaryocyte differentiation, but its precise function remains unknown. In this study, it is confirmed that p21 was expressed at a high level in hypoploid (2N and 4N) and polyploid (at least 8N) human megakaryocytes derived from CD34(+) cells. A high expression of(More)
Because of the scarcity of megakaryocytes in hematopoietic tissues, studying megakaryopoiesis heavily relies on the availability of appropriate cellular models. Here, we report the establishment of a new mouse embryonic stem (ES) cell-derived megakaryocytic cell line, MKD1. The cells are factor-dependent, their cell surface immunophenotype and gene(More)
(4217 articles) Neoplasia (3094 articles) Hematopoiesis and Stem Cells Articles on similar topics can be found in the following Blood collections Information about subscriptions and ASH membership may be found online at: articles must include the digital object identifier (DOIs) and date of initial publication. priority; they are indexed by PubMed from(More)
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