Heather Sasinowska

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We have developed an algorithm which combines data obtained from restriction digestion experiments and hybridization experiments to construct robust physical maps of whole chromosomes. The algorithm has been incorporated into a program which accepts hybridization data consisting of an unordered hybridization matrix and fingerprinting data containing band(More)
Bacterial artificial chromosome (BAC) clones are effective mapping and sequencing reagents for use with a wide variety of small and large genomes. This report describes research aimed at determining the genome structure of Ochrobactrum anthropi, an opportunistic human pathogen that has potential applications in biodegradation of hazardous organic compounds.(More)
Currently there is a lack of targeted therapies that lead to long-term attenuation or regression of disease in patients with advanced clear cell renal cell carcinoma (ccRCC). Our group has implemented a high-throughput genetic analysis coupled with a high-throughput proliferative screen in order to investigate the genetic contributions of a large cohort of(More)
Renal cell carcinoma comprises 2 to 3% of malignancies in adults with the most prevalent subtype being clear-cell RCC (ccRCC). This type of cancer is well characterized at the genomic and transcriptomic level and is associated with a loss of VHL that results in stabilization of HIF1. The current study focused on evaluating ccRCC stage dependent changes at(More)
This study demonstrated the combined effect of drying and vaporous hydrogen peroxide exposure on inactivating highly pathogenic avian influenza (H5N1) on the non-porous materials glass, Hypalon® rubber glove, and stainless steel. Approximately 7.7 log10 TCID50 (median 50% tissue culture infectious dose)/mL of A/Vietnam/1203/2004 H5N1 in allantoic fluid was(More)
The National Select Agents Registry Program regulates the possession, use, and transfer of biological agents and toxins that have been determined to have the potential to pose a severe threat to public safety, to animal or plant health, or to animal or plant products. The program requires that an accurate and current inventory be maintained for each select(More)
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