Heather Powell

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The objective of this study was to determine the accuracy of administrative data (by use of hospital discharge codes) for measuring comorbidity in patients with heart disease. One thousand seven hundred and sixty-five medical records of subjects admitted to hospital for AMI, unstable angina, angina pectoris, chronic IHD or heart failure were reviewed. The(More)
© The Ecological Society of America www.frontiersinecology.org I this paper, we present a conceptual framework for investigating ecological patterns and processes at regional to continental scales. Ecological phenomena operate across a range of scales (Figure 1), but the development of ecological theory of regions to continents lags behind that of finer(More)
OBJECTIVE To define the evidence for doses of inhaled corticosteroids in asthma and describe this in clinically meaningful, evidence-based terms. DATA SOURCE Cochrane Database of Systematic Reviews. STUDY SELECTION AND DATA EXTRACTION We identified systematic reviews of randomised controlled trials of dosing of inhaled corticosteroids in asthma. Data on(More)
BACKGROUND A key component of many asthma management guidelines is the recommendation for patient education and regular medical review. A number of controlled trials have been conducted to measure the effectiveness of asthma education programmes. These programmes improve patient knowledge, but their impact on health outcomes is less well established. At its(More)
RATIONALE Patients with refractory asthma have persistent symptoms despite maximal treatment with inhaled corticosteroids and long-acting bronchodilators. The availability of add-on therapies is limited, and effective add-on therapies that target noneosinophilic airway inflammation are needed. Macrolide antibiotics, such as clarithromycin, have in vitro(More)
BACKGROUND The addition of a long acting beta agonist (LABA) to inhaled corticosteroid (ICS) therapy can improve asthma symptoms and reduce exacerbations. The addition of LABA may also have an ICS-sparing effect and permit a reduction in ICS maintenance dose. OBJECTIVES To determine the efficacy of adding LABA to maintenance ICS therapy in reducing the(More)
BACKGROUND Combination therapy with long-acting beta-agonists (LABAs)/inhaled corticosteroids (ICSs) has become established as effective maintenance treatment for asthma. OBJECTIVE To compare and contrast the efficacy and safety of LABAs/ICSs against different maintenance ICS strategies in adults with asthma. METHODS Cochrane systematic reviews of(More)
BACKGROUND Asthma education and self-management are key recommendations of asthma management guidelines because they improve health outcomes. There are several different modalities for the delivery of asthma self-management education. OBJECTIVES We evaluated programmes that: 1) Optimised asthma control through inhaled corticosteroid use by regular medical(More)
BACKGROUND Asthma is a common condition during pregnancy and may be associated with adverse perinatal outcomes. OBJECTIVE This meta-analysis sought to establish if maternal asthma is associated with an increased risk of adverse perinatal outcomes, and to determine the size of these effects. SEARCH STRATEGY Electronic databases were searched for the(More)