Mu opioid receptor stimulation activates c-Jun N-terminal kinase 2 by distinct arrestin-dependent and independent mechanisms.Jamie Rose Kuhar, Andrea Bedini, Erica J. Melief, Yen-Chen Chiu, Heather N Striegel, Charles ChavkinCellular signalling2015G protein-coupled receptor desensitization is typically mediated by receptor phosphorylation by G protein-coupled receptor kinase (GRK) and subsequent arrestin binding; morphine, however, was… (More)