Heather N. Loke

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UV irradiation and other stress-activated signals activate the Jun N-terminal kinase (JNK, SAPK) pathway. The induction of JNK activity results in the activation of proto-oncogene c-Jun and activator protein-1 (AP-1) transcriptional activity. Data presented here show that UV mediated the activation of JNK correlated with UV-induced apoptosis and that(More)
Tissue was first cultured in the early 1900s, largely from fragments of lower vertebrate tissue that were kept alive in dishes. Occasionally, cells migrated from the explant, but they rarely divided. In the 1940s and 1950s it became possible to take explants of avian or mammalian tissue and derive either normal cells or, in the case of rodents, continuous(More)
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