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The purpose of this study was to determine whether oligonucleotides the size of siRNA are permeable to gap junctions and whether a specific siRNA for DNA polymerase beta (pol beta) can move from one cell to another via gap junctions, thus allowing one cell to inhibit gene expression in another cell directly. To test this hypothesis, fluorescently labelled(More)
BACKGROUND Surveys have generally found that individuals more likely to use complementary and alternative medicine are female, live in the western United States, are likely to have a health complaint, and have a higher socioeconomic status than do nonusers. What is not known is the extent to which those who use complementary and alternative medicine also(More)
This study combined parent and observational measures to examine the association between aberrant sensory features and restricted, repetitive behaviors in children with autism (N=67) and those with developmental delays (N=42). Confirmatory factor analysis was used to empirically validate three sensory constructs of interest: hyperresponsiveness,(More)
As more applications migrate to the cloud, and as "big data" edges into even more production environments, the performance and simplicity of exchanging data between compute nodes/devices is increasing in importance. An issue central to distributed programming, yet often under-considered, is serialization or pickling, <i>i.e.</i>, persisting runtime objects(More)
Rapid repair of plasma membrane wounds is critical for cellular survival. Muscle fibers are particularly susceptible to injury, and defective sarcolemma resealing causes muscular dystrophy. Caveolae accumulate in dystrophic muscle fibers and caveolin and cavin mutations cause muscle pathology, but the underlying mechanism is unknown. Here we show that(More)
Functional programming (FP) is regularly touted as the way forward for bringing parallel, concurrent, and distributed programming to the mainstream. The popularity of the rationale behind this viewpoint has even led to a number of object-oriented (OO) programming languages outside the Smalltalk tradition adopting functional features such as lambdas and(More)
Massive open online courses (MOOCs) have launched a scale shift in higher education, with several individual MOOCs now boasting tens or hundreds of thousands of participants worldwide. Our MOOC on the principles of functional programming has more than 100,000 registered students to date, and boasts one of the highest rates of completion (19.2%) for its(More)
Living PC12 cells, a model cell type for studying neuronal function, were imaged using the negative feedback mode of a scanning electrochemical microscope (SECM). Six biocompatible redox mediators were successfully identified from a large pool of candidates and were then used for imaging PC12 cells before and after exposure to nerve growth factor (NGF).(More)
Functional programming (FP) is regularly touted as the way forward for bringing parallel, concurrent, and distributed programming to the mainstream. However , despite this established viewpoint, reliably distributing function closures over a network, or using them in concurrent environments nonetheless remains a challenge across FP and OO languages. Our(More)