Heather M. Bowen

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Mice fed a high-fat diet are reported to be resistant to peripheral injections of leptin. We previously failed to induce leptin resistance in female mice fed a high-fat diet for 15 weeks. Therefore, we measured the responsiveness to peripheral infusions (10 microg/day) of leptin, and the responsiveness to third ventricle injections of leptin (1 microg) in(More)
  • MARIE MADDEN BOWEN, Ruth Harris, +8 authors Emilia Papaconstininou
  • 2002
Genetically obese mice exhibit mutations in leptin or its receptor and are inappropriate for studying human obesity, a hyperleptinemic condition with an intact leptin system. High-fat diets reportedly induce resistance to peripherally administered leptin and may better represent obese humans. 35-day-old, C57BL/6J high-fat (45% kcal fat) fed mice housed(More)
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