Heather Levin

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In 1939 Gladstone clearly demonstrated the phenomenon of amino acid antagonism and showed its relationship to the nutrition of the pathogen Bacillus anthracis. Among the interrelationships involving specific amino acids was the ability of threonine to remove the toxic effects of serine and vice versa. Snell and Guirard (1943) noted the inhibition of growth(More)
Exposure to genotoxins such as ethanol-derived acetaldehyde leads to DNA damage and liver injury, and promotes the development of cancer. We report here a major role for the TGF-β/Smad3 adaptor β2-Spectrin (β2SP, gene Sptbn1) in maintaining genomic stability following alcohol-induced DNA damage. β2SP supports DNA repair through β2SP-dependent activation of(More)
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