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Mitochondrial Rac1 GTPase Import and Electron Transfer from Cytochrome c Are Required for Pulmonary Fibrosis*
- Heather L Osborn-Heaford, A. Ryan, A. Carter
- Biology, MedicineThe Journal of Biological Chemistry
- 8 December 2011
This study shows that Rac1 is localized in the mitochondria of alveolar macrophages from asbestosis patients, and mitochondrial import requires the C-terminal cysteine of Rac1 (Cys-189), which is post-translationally modified by geranylgeranylation.