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Active contour segmentation and its robust implementation using level sets have been studied thoroughly in the medical image analysis literature. Despite the availability of these powerful methods, clinical research still largely relies on manual slice-by-slice outlining for anatomical structure segmentation. To bridge the gap between methodological(More)
Magnetic resonance imaging (MRI) of brain structures and function is uniquely suited to characterize the range of neuroanatomical and physiological changes that characterize the autism phenotype as it develops over time. In this review, we examine the scientific literature in MRI as applied to autism and related areas, over approximately the last decade,(More)
OBJECTIVE To assess empirically the competency of patients with Alzheimer's disease (AD) to consent to medical treatment under different legal standards (LSs). DESIGN Comparison of normal older subjects and patients with AD on measures of competency to consent to medical treatment. SETTING University medical center. SUBJECTS Normal older control(More)
OBJECTIVE To identify neuropsychologic predictors of competency performance and status in Alzheimer's disease (AD) using a specific legal standard (LS). This study is a follow-up to the competency assessment research reported in this issue of the archives. DESIGN Univariate and multivariate analyses of independent neuropsychologic test measures with a(More)
  • Kevin Gorczowskia, Martin Stynera, Ja Yeon Jeonga, J. S. Marronc, Joseph Pivenb, Heather Cody +2 others
  • 2007
A main focus of statistical shape analysis is the description of variability of a population of geometric objects. In this paper, we present work towards modeling the shape and pose variability of sets of multiple objects. Principal geodesic analysis (PGA) is the extension of the standard technique of principal component analysis (PCA) into the nonlinear(More)
As part of the NIMH Genetics Initiative Alzheimer's Disease (AD) Study Group, a brief structured telephone interview to distinguish individuals with normal cognitive functioning from those with changes in cognition and daily functioning suggestive of early AD was developed. The Structured Telephone Interview for Dementia Assessment (STIDA), yields a(More)
We present a new software package for interactive segmen-tation of 3D images by geodesic snakes, with manual editing. Several variants of level set snakes are incorporated, including both gradient-magnitude based snakes as well as region-competition snakes. A complete segmentation pipeline, including image preprocessing, bubble initializa-tion and parameter(More)
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