Heather C. Brenhouse

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Nonsteroidal Anti-Inflammatory Treatment Prevents Delayed Effects of Early Life Stress in Rats

Heather C. Brenhouse, Susan Andersen
Biological Psychiatry
2011

BACKGROUND Early developmental insults can cause dysfunction within parvalbumin (PVB)-containing interneurons in the prefrontal cortex. The neuropsychiatric disorders associated with such dysfunction… (More)

Developmental trajectories during adolescence in males and females: A cross-species understanding of underlying brain changes

Heather C. Brenhouse, Susan Andersen
Neuroscience & Biobehavioral Reviews
2011

Adolescence is a transitional period between childhood and adulthood that encompasses vast changes within brain systems that parallel some, but not all, behavioral changes. Elevations in emotional… (More)

Transient D1 dopamine receptor expression on prefrontal cortex projection neurons: relationship to enhanced motivational salience of drug cues in adolescence.

Heather C. Brenhouse, Kai-C Sonntag, Susan Andersen
The Journal of neuroscience : the official…
2008

Adolescence is a transitional period during development that is associated with a greater likelihood of addiction to drugs than any other age. In the prefrontal cortex (PFC), D(1) dopamine receptors… (More)

Delayed extinction and stronger reinstatement of cocaine conditioned place preference in adolescent rats, compared to adults.

Heather C. Brenhouse, Susan Andersen
Behavioral neuroscience
2008

Adolescence is a transitional period during development that is associated with a greater likelihood of addiction to drugs than any other age. One possibility for this observation is that learned… (More)

An overview of maternal separation effects on behavioural outcomes in mice: Evidence from a four-stage methodological systematic review

Saulo Gantes Tractenberg, Mateus Luz Levandowski, +5 authors Rodrigo Grassi-Oliveira
Neuroscience & Biobehavioral Reviews
2016

Early life stress (ELS) developmental effects have been widely studied by preclinical researchers. Despite the growing body of evidence from ELS models, such as the maternal separation paradigm, the… (More)

Evidence for a neuroinflammatory mechanism in delayed effects of early life adversity in rats: Relationship to cortical NMDA receptor expression

Andréa Wieck, Susan Andersen, Heather C. Brenhouse
Brain, Behavior, and Immunity
2013

Postnatal maternal separation in rats causes a reduction of GABAergic parvalbumin-containing interneurons in the prefrontal cortex that first occurs in adolescence. This parvalbumin loss can be… (More)

Enhancing the salience of dullness: behavioral and pharmacological strategies to facilitate extinction of drug-cue associations in adolescent rats

Heather C. Brenhouse, Kelly M Dumais, Susan Andersen
Neuroscience
2010

Extinction of drug-seeking is an integral part of addiction treatment, and can profoundly reverse or ameliorate the harmful consequences of drug use. These consequences may be the most deleterious… (More)

Early Life Adversity Alters the Developmental Profiles of Addiction-Related Prefrontal Cortex Circuitry

Heather C. Brenhouse, Jodi L. Lukkes, Susan Andersen
Brain sciences
2013

Early adverse experience is a well-known risk factor for addictive behaviors later in life. Drug addiction typically manifests during adolescence in parallel with the later-developing prefrontal… (More)

Broken or maladaptive? Altered trajectories in neuroinflammation and behavior after early life adversity

Prabarna Ganguly, Heather C. Brenhouse
Developmental Cognitive Neuroscience
2015

Exposure to adversity and stress early in development yields vulnerability to mental illnesses throughout the lifespan. Growing evidence suggests that this vulnerability has mechanistic origins… (More)

Immunoadolescence: Neuroimmune development and adolescent behavior

Heather C. Brenhouse, Jaclyn M. Schwarz
Neuroscience & Biobehavioral Reviews
2016

The brain is increasingly appreciated to be a constantly rewired organ that yields age-specific behaviors and responses to the environment. Adolescence in particular is a unique period characterized… (More)

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