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The accelerating availability of molecular sequences, particularly the sequences of entire genomes, has transformed both the theory and practice of experimental biology. Where once biochemists characterized proteins by their diverse activities and abundances, and geneticists characterized genes by the phenotypes of their mutations, all biologists now(More)
OBJECTIVE To examine psychometric properties of the Self-Care Inventory-revised (SCI-R), a self-report measure of perceived adherence to diabetes self-care recommendations, among adults with diabetes. RESEARCH DESIGN AND METHODS We used three data sets of adult type 1 and type 2 diabetic patients to examine psychometric properties of the SCI-R. Principal(More)
Wasting of lean tissue as a consequence of metabolic acidosis is a serious problem in patients with chronic renal failure. A possible contributor is inhibition by low pH of the System A (SNAT2) transporter, which carries the amino acid L-glutamine (L-Gln) into muscle cells. The aim of this study was to determine the effect of selective SNAT2 inhibition on(More)
There is a long history of science fiction novels and movies that feature aliens from other worlds conquering our planet, either overtly as in The War of the Worlds, or covertly as in The Arrival. Aliens have also infiltrated video games, starting with Space Invaders, and more recently with Aliens vs. Predator. Extraterrestrials have also appeared in(More)
Indoleamine 2,3-dioxygenase (IDO) is the first enzyme in the kynurenine pathway. The kynurenines formed in this pathway chemically modify proteins and cause apoptosis in cells. Evidence suggests that kynurenines and their protein modifications are involved in cataract formation, but this has yet to be directly demonstrated. We generated transgenic (Tg)(More)
Students interacted with an Intelligent Tutoring System called Operation ARIES!,which involves two agents interacting with the human in natural language trialogs. We investigated the conditions in which the length of the students' contributions is correlated with learning. Word count and the proportional learning gains scores were correlated, especially in(More)
BACKGROUND In chronic renal failure, metabolic acidosis increases protein degradation (PD) in skeletal muscle, an effect which in vivo requires glucocorticoid (GC). This disorder is poorly understood, but can be studied in vitro using L6G8C5 rat skeletal muscle cells. Two potential confounding factors in studies of PD in culture are apoptosis and(More)
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