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Antibody blockade of the Cripto CFC domain suppresses tumor cell growth in vivo.
Cripto, a cell surface-associated protein belonging to the EGF-CFC family of growth factor-like molecules, is overexpressed in many human solid tumors, including 70-80% of breast and colon tumors,Expand
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Cripto-1 Activates Nodal- and ALK4-Dependent and -Independent Signaling Pathways in Mammary Epithelial Cells
ABSTRACT Cripto-1 (CR-1), an epidermal growth factor-CFC (EGF-CFC) family member, has a demonstrated role in embryogenesis and mammary gland development and is overexpressed in several human tumors.Expand
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A Nodal- and ALK4-independent signaling pathway activated by Cripto-1 through Glypican-1 and c-Src.
Human Cripto-1 (CR-1) is a member of the epidermal growth factor-Cripto FRL1 Cryptic family that has been shown to function as a coreceptor with the type I Activin serine-threonine kinase receptorExpand
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Human Cripto-1 overexpression in the mouse mammary gland results in the development of hyperplasia and adenocarcinoma
Human Cripto-1 (CR-1) is overexpressed in approximately 80% of human breast, colon and lung carcinomas. Mouse Cr-1 upregulation is also observed in a number of transgenic (Tg) mouse mammary tumors.Expand
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Detection and localization of Cripto‐1 binding in mouse mammary epithelial cells and in the mouse mammary gland using an immunoglobulin–cripto‐1 fusion protein †
Human Cripto‐1 (CR‐1), a member of the epidermal growth factor‐CFC (EGF‐CFC) family of peptides, is expressed in the developing mouse mammary gland and can modulate mammary epithelial cell migration,Expand
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Cells Signaling Pathways in Mammary Epithelial ALK 4-Dependent and-Independent Cripto-1 Activates Nodal-and
10.1128/MCB.22.8.2586-2597.2002. 2002, 22(8):2586. DOI: Mol. Cell. Biol. and David S. Salomon Sanicola Kenney, Andreas Ebert, Kevin P. Williams, Michele Antonella De Luca, Youping Sun, Nadia Khan,Expand
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Nodal and Cripto-1: Embryonic Pattern Formation Genes Involved in Mammary Gland Development and Tumorigenesis
Members of the TGFβ superfamily and EGF-CFC family, such as Nodal and Cripto, are important mediators of anterior-posterior and left-right axis specification during embryogenesis. In this paper, weExpand
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Comparison of HIV-1 Viral Load between Abbott m2000 and Roche COBAS TaqMan Methods
Accurate quantification of HIV-1 viral load (VL) is crucial for disease monitoring and management. This study was designed to compare HIV-1 VL determination between two of the major commercialExpand
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Advances in Brief A Nodal-and ALK 4-independent Signaling Pathway Activated by Cripto-1 through Glypican-1 and cSrc 1
Human Cripto-1 (CR-1) is a member of the epidermal growth factorCripto FRL1 Cryptic family that has been shown to function as a coreceptor with the type I Activin serine-threonine kinase receptorExpand
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Reading Othello in Kentucky
I Reading Lolita in Tehran, Azar Nafisi gives an account of a clandestine class she taught at her home in Tehran for seven young women. In several novels, among them Lolita, The Great Gatsby, DaisyExpand