OBJECTIVE To analyse the feasibility, cost and performance of rapid tuberculosis (TB) molecular and culture systems, in a high multidrug-resistant TB (MDR TB) middle-income region (Samara, Russia) and provide evidence for WHO policy change. METHODS Performance and cost evaluation was conducted to compare the BACTEC MGIT 960 system for culture and drug… (More)
Xpert MTB/RIF is a major advance for TB diagnostics, especially for multidrug-resistant (MDR) TB and HIV-associated TB. But implementation concerns including cost, technical support requirements, and challenging demands of providing second-line TB drugs for diagnosed MDR-TB cases call for gradual, careful introduction based on country circumstances.
Several genetic systems that allow the use of iron-protoporphyrin IX (heme) have been described for the pathogenic bacterium Neisseria meningitidis. However, many questions about the process of heme acquisition and utilization remain to be answered. To isolate and analyze unidentified genes that play a role in heme iron uptake and utilization, a Himar1… (More)
OBJECTIVE To assess the performance of symptom-based screening for tuberculosis (TB), alone and with chest radiography among people living with HIV (PLHIV), including pregnant women, in Western Kenya. DESIGN Prospective cohort study. METHODS PLHIV from 15 randomly-selected HIV clinics were screened with three clinical algorithms [World Health… (More)
BACKGROUND Borderline personality disorder (BPD) and avoidant personality disorder (AvPD) are characterized by hyper-reactivity to negatively-perceived interpersonal cues, yet they differ in degree of affective instability. Recent work has begun to elucidate the neural (structural and functional) and cognitive-behavioral underpinnings of BPD, although some… (More)
We report on an innovation in teaching and learning designed to extend the collaborative learning of Problem-Based Learning (PBL), that occurs during the first two years of a four year graduate entry medical program, to a capstone learning experience to assist the transition to a hospital based Year 3. During the last five weeks of Year 2 the PBL sessions… (More)