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Anti-tubercular Activity of Pyrazinamide is Independent of trans-Translation and RpsA
Pyrazinamide (PZA) is a first line anti-tubercular drug for which the mechanism of action remains unresolved. Recently, it was proposed that the active form of PZA, pyrazinoic acid (POA), disruptsExpand
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Human Cells Require Non-stop Ribosome Rescue Activity in Mitochondria
Bacteria use trans-translation and the alternative rescue factors ArfA (P36675) and ArfB (Q9A8Y3) to hydrolyze peptidyl-tRNA on ribosomes that stall near the 3' end of an mRNA during proteinExpand
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Resolving nonstop translation complexes is a matter of life or death.
Problems during gene expression can result in a ribosome that has translated to the 3' end of an mRNA without terminating at a stop codon, forming a nonstop translation complex. The nonstopExpand
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Resident microbiota affect Bordetella pertussis infectious dose and host specificity.
Before contacting host tissues, invading pathogens directly or indirectly interact with host microbiota, but the effects of such interactions on the initial stages of infection are poorly understood.Expand
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Horizontally acquired divergent O-antigen contributes to escape from cross-immunity in the classical bordetellae
BackgroundHorizontal gene transfer (HGT) allows for rapid spread of genetic material between species, increasing genetic and phenotypic diversity. Although HGT contributes to adaptation and isExpand
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Host Specificity of Ovine Bordetella parapertussis and the Role of Complement
The classical bordetellae are comprised of three subspecies that differ from broad to very limited host specificity. Although several lineages appear to have specialized to particular host species,Expand
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Release of Nonstop Ribosomes Is Essential
ABSTRACT Bacterial ribosomes frequently translate to the 3′ end of an mRNA without terminating at a stop codon. Almost all bacteria use the transfer-messenger RNA (tmRNA)-based trans-translationExpand
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Ribosome dimerization protects the small subunit.
When nutrients become scarce, bacteria can enter an extended state of quiescence. A major challenge of this state is how to preserve ribosomes for the return to favorable conditions. Here, we showExpand
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A Wolf in Sheep's Clothing: Chromosomal Pathogenicity Islands Co-opt Phage Capsids to Facilitate Horizontal Spread.
Fillol-Salom et al. describe a mechanism by which an Escherichia coli pathogenicity island is preferentially packaged into a phage particle, thus promoting the spread of pathogenic traits amongExpand
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Ribosome dimerization prevents loss of essential ribosomal proteins during quiescence
The formation of ribosome dimers during periods of quiescence is widespread among bacteria and some higher eukaryotes. However, the mechanistic importance of dimerization is not well understood. InExpand