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AIM Free fatty acid-induced lipotoxicity plays a crucial role in the progression of nonalcoholic fatty liver disease (NAFLD). In the present study we investigated the effects of a high-fat diet and free fatty acids on the autophagic process in hepatocytes in vivo and in vitro and the underlying mechanisms. METHODS LC3-II expression, a hallmark of(More)
BACKGROUND Our previous studies showed that ZBTB20, a new BTB/POZ-domain gene, could negatively regulate α feto-protein and other liver-specific genes, concerning such as bio-transformation, glucose metabolism and the regulation of the somatotropic hormonal axis. The aim of this study is to determine the potential clinical implications of ZBTB20 in(More)
CKAP4, one kind of type II trans-membrane protein, plays an important role to maintain endoplasmic reticulum structure and inhibits the proliferation of bladder cancer cells by combining its ligand anti-proliferative factor (APF). However, the biological function of CKAP4 in the progression of liver cancer has not been clearly demonstrated. In the present(More)
Distributed Hash Tables (DHTs) provide a scalable solution for data sharing in P2P systems. To achieve fault tolerance and ensure high data availability, DHTs typically rely on data replication. However, nodes churn, lacking of global view and existence of malicious nodes in P2P environment bring new challenges to the concurrency control for replicated(More)
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