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The activation of kainate receptors modulates GABAergic synaptic transmission, but the mechanisms are currently a matter of intense debate. In the basolateral amygdala (BLA), the glutamate receptor 5 (GluR5) subunit of kainate receptors is heavily expressed, and GluR5 antagonists block a novel form of synaptic plasticity; yet little is known about the role(More)
The occurrence of stress and anxiety disorders has been closely associated with alterations of the amygdala GABAergic system. In these disorders, dysregulation of the serotonergic system, a very important modulator of the amygdala GABAergic system, is also well recognized. The present study, utilizing a learned helplessness stress rat model, was designed to(More)
In Huntington disease (HD), polyglutamine expansion causes the disease protein huntingtin to aggregate and accumulate in the nucleus and cytoplasm. The cytoplasmic huntingtin aggregates are found in axonal terminals and electrophysiological studies show that mutant huntingtin affects synaptic neurotransmission. However, the biochemical basis for(More)
Huntington's disease (HD) is caused by polyglutamine (polyQ) expansion in huntingtin (htt), a large (350 kDa) protein that localizes predominantly to the cytoplasm. Proteolytic cleavage of mutant htt yields polyQ-containing N-terminal fragments that are prone to misfolding and aggregation. Disease progression in HD transgenic models correlates with(More)
Huntington's disease (HD) mouse models that express N-terminal huntingtin fragments show rapid disease progression and have been used for developing therapeutics. However, light microscopy reveals no significant neurodegeneration in these mice. It remains unclear how mutant huntingtin induces neurodegeneration. Using caspase staining, terminal(More)
Huntington's disease (HD) is characterized by a progressive loss of neurons in the striatum and cerebral cortex and is caused by a CAG repeat expansion in the gene encoding huntingtin. Mice with the mutation inserted into their own huntingtin gene (knock-in mice) are, genetically, the best models of the human disease. Here we show for the first time that(More)
—Scalable video coding is an ongoing standard, and the current working draft (WD) is an extension of H.264/AVC. In the WD, an exhaustive search technique is employed to select the best coding mode for each macroblock. This technique achieves the highest possible coding efficiency, but it results in extremely large encoding time which obstructs it from(More)
Tattoos can provide useful information related to criminal gang activity. Law enforcement can use the information embedded in tattoos to identify and track the criminal history of a suspect. For matching processes, tattoo images are difficult to use due to problems such as deformations and weak edge structures. In this paper we describe a tattoo image(More)
In this paper we present our submission to the NIST Tattoo Recognition Technology - Challenge (Tatt-C) that was held in early 2015. The goal of our work is to match a subregion of an tattoo image to another image. We introduce an image descriptor that combines SIFT (Scale Invariant Feature Transformation) and LSS (local self similarity). The SIFT descriptor(More)
In this paper we introduce two different automatic tattoo localization methods. The first one is a center-surround feature localization method. It combines a center-surround filter with skin and edge features based on the observation that the skin area surrounding the tattoo is homogeneously smooth and skin-colored. The second method is a graph-cut tattoo(More)