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Signalling by the Wnt family of secreted lipoproteins has essential functions in development and disease. The canonical Wnt/beta-catenin pathway requires a single-span transmembrane receptor, low-density lipoprotein (LDL)-receptor-related protein 6 (LRP6), whose phosphorylation at multiple PPPSP motifs is induced upon stimulation by Wnt and is critical for(More)
This study investigated the use of surface electromyography (EMG) combined with pattern recognition (PR) to identify user locomotion modes. Due to the nonstationary characteristics of leg EMG signals during locomotion, a new phase-dependent EMG PR strategy was proposed for classifying the user's locomotion modes. The variables of the system were studied for(More)
Tuberous sclerosis complex is a dominant disorder that leads to the development of benign tumors in multiple organs. We have isolated a mutation in the Drosophila homolog of TSC1 (Tsc1). Cells mutant for Tsc1 are dramatically increased in size yet differentiate normally. Organ size is also increased in tissues that contain a majority of mutant cells. Clones(More)
The original use of biofeedback to train single muscle activity in static positions or movement unrelated to function did not correlate well to motor function improvements in patients with central nervous system injuries. The concept of task-oriented repetitive training suggests that biofeedback therapy should be delivered during functionally related(More)
The Wnt/beta-catenin signaling pathway plays essential roles in cell proliferation and differentiation, and deregulated beta-catenin protein levels lead to many types of human cancers. On activation by Wnt, the Wnt co-receptor LDL receptor related protein 6 (LRP6) is phosphorylated at multiple conserved intracellular PPPSPXS motifs by glycogen synthase(More)
The newly developed transcription activator-like effector protein (TALE) and clustered regularly interspaced short palindromic repeats/Cas9 transcription factors (TF) offered a powerful and precise approach for modulating gene expression. In this article, we systematically investigated the potential of these new tools in activating the stringently silenced(More)
In this Letter, by utilizing the Lyapunov functional method, applying M-matrix and topological degree theory, we analyze the global exponential stability and the existence of periodic solutions of a class of recurrent neural networks with delays. Some simple and new sufficient conditions ensuring existence, uniqueness and global exponential stability of the(More)
The synchronization problem is studied in this paper for nonidentical chaotic neural networks with time delays, where the mismatched parameters are taken into account. An integral sliding mode control approach is proposed to address it. As a first step, a proper sliding surface is constructed. Based on the drive-response concept and Lyapunov stability(More)
Wireless sensor networks have gained considerable attention in the past few years. In this article we present a WSN simulator - OMNET++. Through compare with some well-known simulator proves OMNET++ has better performance than NS2 and OPNET. We demonstrate the use of the WSN simulation by implementing Directed Diffusion protocols, and perform performance(More)