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We studied the early pattern of neural tube (NT) vascularization in quail embryos and chick-quail chimeras. Angioblasts appeared first in the dorsal third at Hamburger and Hamilton (HH) stage 19 as single, migrating cells. Their distribution did not correspond to a segmental pattern. After this initial dorsal immigration, endothelial sprouts invaded the NT(More)
  • H Kurz
  • 2000
Angiogenesis is a key prerequisite for growth in all vertebrate embryos and in many tumors. Rapid growth requires efficient transport of oxygen and metabolites. Hence, for a better understanding of tissue growth, biophysical properties of vascular systems, in addition to their molecular mechanisms, need to be investigated. The purpose of this article is(More)
Fgf-8 encodes a secreted signaling molecule mediating key roles in embryonic patterning. This study analyzes the expression pattern, regulation, and function of this growth factor in the paraxial mesoderm of the avian embryo. In the mature somite, expression of Fgf-8 is restricted to a subpopulation of myotome cells, comprising most, but not all, epaxial(More)
The origin of vascular pericytes (PCs) and smooth muscle cells (vSMCs) in the brain has hitherto remained an open question. In the present study, we used the quail-chick chimerization technique to elucidate the lineage of cranial PCs/vSMCs. We transplanted complete halves of brain anlagen, or dorsal (presumptive neural crest [NC]) or ventral cranial neural(More)
We asked, whether, in the blood of avian embryos, endothelial precursor cells circulate that actually contribute to the growing vascular system in and around the central nervous system (CNS). We compared the morphology and distribution of QH1-positive cells after transplantation of quail paraxial mesoderm, after blood transfusion, in quail-chick parabiosis,(More)
We introduce and discuss a new method for segmentation and classification of cells from 3D tissue probes. The anisotropic 3D volumetric data of fluorescent marked cell nuclei is recorded by a confo-cal laser scanning microscope (LSM). Voxel-wise gray scale features (see accompaning paper [1][2]), invariant towards 3D rotation of its neighborhood , are(More)
We report on an enhanced computational framework for simulating flow-tissue interactions that significantly expands the capabilities of our previous model [1]. We adhere to the basic structural concept of the so-called intus-susceptive growth and remodeling which does not only generate capillaries and terminal vessels but also rebuilds them into a highly(More)
The design of living beings is not only a matter of molecular biology but also of geometry and physics. This was once more demonstrated with a biophysical model by G. B. West et al. (1) that had been fine-tuned to predict the famous scaling law of metabolism (2), namely a 3/4 power relation between body mass and energy consumption. While properties and(More)
We have studied the kinetics of somite cells with an antibody against proliferating cell nuclear antigen (PCNA/cyclin) in human and chick embryos, and with the BrdU anti-BrdU method in chick embryos, to investigate whether the metameric pattern of the developing vertebral column can be explained by different proliferation rates. Furthermore we applied(More)