Hayley A. Mattison

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In an in vitro co-culture system of astrocytes and neurons, stimulation of cholinergic muscarinic receptors in astrocytes had been shown to cause neuritogenesis in hippocampal neurons, and this effect was inhibited by ethanol. The present study sought to confirm these earlier findings in a more complex system, in vitro rat hippocampal slices in culture.(More)
GluA2-lacking, calcium-permeable α-amino-3-hydroxy-5-methylisoxazole-4-propionate receptors (AMPARs) have unique properties, but their presence at excitatory synapses in pyramidal cells is controversial. We have tested certain predictions of the model that such receptors are present in CA1 cells and show here that the polyamine spermine, but not(More)
Dendritic spines form the postsynaptic half of the synapse but how they form during CNS development remains uncertain, as are the factors that promote their morphological and physiological maturation. One hypothesis posits that filopodia, long motile dendritic processes that are present prior to spine formation, are the precursors to spines. Another(More)
19 GluA2-lacking, calcium-permeable AMPA receptors have unique properties, but their presence 20 at excitatory synapses in pyramidal cells is controversial. We have tested certain predictions of 21 the model that such receptors are present in CA1 cells and show here that the polyamine 22 spermine, but not philanthotoxin, causes use-dependent inhibition of(More)
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