Haydar Yuksek

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Nine new 1,3,4-trisubstituted-4,5-dihydro-1H-1,2,4-triazol-5-ones were synthesized and characterized by elemental analysis, 1H NMR, IR and UV spectra. These new and 30 recently reported 3,4-disubstituted- and 1,3,4-trisubstituted-4,5-dihydro-1H-1,3,4-triazol-5-ones were screened for antibacterial, antitumor and anti-HIV activities.
In the present study, 3-alkyl(aryl)-4-amino-4,5-dihydro-1H-1,2,4-triazol-5-ones (1a, b, d–g) reacted with 3-phenoxybenzaldehyde to afford 3-alkyl(aryl)-4-(3-phenoxy-benzylidenamino-4,5-dihydro-1H-1,2,4-triazol-5-ones (2a, b, d–g). Then, the acetylation reactions of compounds 2a and 2d–g were investigated. The structures of 11 new compounds were established(More)
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