Hayao Okamura

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The approach for predicting the degree of drug-induced liver injury (DILI) risk was investigated quantitatively in a modified multiparametric assay using HepaRG cells. Thirty-eight drugs were classified by DILI risk into five categories based on drug labels approved by the Food and Drug Administration (FDA) as follows: withdrawn (WDN), boxed warning (BW),(More)
The utility of HepaRG cells as an in vitro cell-based assay system for assessing drug-induced liver injury (DILI) risk was investigated. Seventeen DILI-positive and 15 DILI-negative drugs were selected for the assay. HepaRG cells were treated with each drug for 24h at concentrations that were 1.6-, 6.3-, 25-, and 100-fold the therapeutic maximum plasma(More)
Using 13 patients undergoing operation of the bile duct, cefmenoxime (CMX) transport into the bile and the gallbladder tissue was investigated. One gram of CMX was administered through drip infusion over 30 minutes every 12 hours. CMX concentration in bile was measured for samples surgically collected about 103 minutes (75-141 minutes) after the start of(More)
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