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Muscle fibers of the masseter muscle of mice which had been fed a fine-grained diet for various periods were studied histochemically and morphometrically. The diameters of both extrafusal and intrafusal muscle fibers decreased with time in mice fed a fine-grained diet, compared with those of control mice. In animals maintained on the special diet for 160(More)
The role of actin bundles on the heart looping of chick embryos was examined by using cytochalasin B, which binds to the barbed end of actin filaments and inhibits association of the subunits. It was applied to embryos cultured according to New's method. Looping did not occur when cytochalasin B was applied diffusely in the medium. Further, we disorganized(More)
It has been suggested that some mitochondrial genes are important in cellular senescence. In order to identify the mitochondrial genes that are involved in cellular senescence, we have constructed a cDNA library from senescent human vascular endothelial cells and isolated 86 senescence-specific cDNA clones by differential screening. Among the clones, we(More)
Intraepithelial lymphocytes (IELs) play an important role in maintaining the physiology of the small intestine. The majority of mouse IELs express CD8αα and are either γδ or αβ T cells. Although the development and homing of CD8αα IELs have been studied in some detail, the factors controlling their homeostasis and positioning are incompletely understood.(More)
Cathepsin B (CTSB) is a proteolytic enzyme potentially modulating angiogenic processes and extracellular matrix remodeling. While matrix metalloproteinases are shown to be implicated in tissue fibrosis and vasculopathy associated with systemic sclerosis (SSc), the role of cathepsins in this disease has not been well studied. The aim of this study is to(More)
A possible contribution of visfatin to the resolution of skin sclerosis in patients with diffuse cutaneous systemic sclerosis via a direct anti-fibrotic effect on dermal fibroblasts and Th1 polarization of the immune response Abstract Objective. Visfatin is a member of the adipocytokines with pro-fibrotic, pro-inflammatory and immuno-modulating properties(More)
Psoriasis is an inflammatory skin disease with accelerated epidermal cell turnover. Neutrophil accumulation in the skin is one of the histological characteristics of psoriasis. However, the precise mechanism and role of neutrophil infiltration remain largely unknown. In this article, we show that orchestrated action of CXCR2 and leukotriene B 4 receptor(More)
The 2008 WHO–EORTC classification for cutaneous lymphomas identifies 3 main subtypes of primary cuta-neous B-cell lymphoma, including primary cutaneous diffuse large B-cell lymphoma, leg-type (PCLBCL, LT) (1), which is predominantly found in elderly people and has clinical features of erythematous or violaceous multiple tumours, frequent relapses, and a(More)
In the masticatory muscles, neuromuscular spindles have a very important role in controlling the jaw movement since they act as stretch receptors in skeletal muscles. The continuous intake of fine-grained diet which is easily chewable leads to degeneration of the sensory endings of Ia fibers in many muscle spindles of the mouse masseter muscle in only 120 d(More)