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Comparison of multiple DNA dyes for real-time PCR: effects of dye concentration and sequence composition on DNA amplification and melting temperature
The importance of real-time polymerase chain reaction (PCR) has increased steadily in clinical applications over the last decade. Many applications utilize SYBR Green I dye to follow the accumulationExpand
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Genome‐wide association studies of cerebral white matter lesion burden
White matter hyperintensities (WMHs) detectable by magnetic resonance imaging are part of the spectrum of vascular injury associated with aging of the brain and are thought to reflect ischemic damageExpand
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Common variants at 6q22 and 17q21 are associated with intracranial volume
Competing interests statement The authors declare no competing financial interests related to this manuscript. Abstract During aging, intracranial volume remains unchanged and represents maximallyExpand
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Heterogeneity in White Blood Cells Has Potential to Confound DNA Methylation Measurements
Epigenetic studies are commonly conducted on DNA from tissue samples. However, tissues are ensembles of cells that may each have their own epigenetic profile, and therefore inter-individual cellularExpand
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Common variants at 6q22 and 17q21 are associated with intracranial volume
During aging, intracranial volume remains unchanged and represents maximally attained brain size, while various interacting biological phenomena lead to brain volume loss. Consequently, intracranialExpand
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An inexpensive and simple method for thermally stable immobilization of DNA on an unmodified glass surface: UV linking of poly(T)10-poly(C)10-tagged DNA probes.
Microarrays printed on glass slides are often constructed by covalently linking modified oligonucleotide probes to a derivatized surface at considerable expense. In this article, we demonstrate thatExpand
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An oligonucleotide-tagged microarray for routine diagnostics of colon cancer by genotyping KRAS mutations.
Colorectal cancer (CRC) is one of the most prevalent types of cancer, causing significant morbidity and mortality worldwide. CRC is curable if diagnosed at an early stage. Mutations in the oncogeneExpand
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Microsystems for DNA amplification and analysis
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