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In April 1990, 488 marine fish belonging to 30 species from central Philippine waters were examined for flesh parasitic infections that may affect their consumability. One species of hemirhamphids and 3 species of belonids harboured plerocercoids of Otobothrium penetrans Linton, 1907 (Proceedings of the U.S. National Museum 33, 85-126). This is the first(More)
The development of in vitro dissolution tests using the paddle and basket apparatus is described with respect to the qualification/validation of the testing procedure. Three examples of immediate release products containing phenoxymethylpenicillin potassium, glimepiride, and levofloxacin providing different solubility characteristics are evaluated. The(More)
More than 30 years have been devoted to characterizing the biopharmaceutical properties of drug products. The numerous tests developed are generally based on two distinct methodologies--a closed system (beaker method) and an open system (flow-through method). Selected methods were finally standardized and described in such pharmacopoeias as Ph. Eur. 2, USP(More)
A new nonlinear reconstruction method for tomosynthesis is described. This method is suited for "dilute" objects, i.e., objects in which most of the voxels have negligibly small absorption. Images of blood vessels filled with contrast material approximate this condition if the background is subtracted. The technique has been tested experimentally using a(More)
PURPOSE Focus on hygienic management in ambulances is presented based on findings from hygienic microbiological sampling. METHODS In 44 ambulances, the handwashing area, equipment for artificial respiration, insufflation, intubation, aspiration, intravasal catheterisation, blood-pressure measurement, and sterile materials storage were examined(More)
From the marketed drug product Roxane(R) 75 mg C/MR capsules (roxatidine controlled/modified-release capsules), an in vitro/in vivo comparison was performed to demonstrate a 1:1 correlation between in vitro and in vivo dissolution, and, furthermore, to ensure bioequivalence of the roxatidine controlled/modified-release (C/MR) capsules exhibiting dissolution(More)