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Photoactivation of Ligands for Extrinsically and Intrinsically Triggered Disassembly of Amphiphilic Nanoassemblies.
TLDR
A design strategy for amphiphilic nanoassemblies with specific response to the concurrent presence of two different inputs is presented, enabled by photocaging a ligand moiety that is capable of binding to a specific protein.
Propagation of Enzyme-Induced Surface Events inside Polymer Nanoassemblies for a Fast and Tunable Response.
We report a new molecular design strategy that allows for the propagation of surface enzymatic events inside a supramolecular assembly for accelerated molecular release. The approach addresses a key
Syntheses and evaluation of multicaulin and miltirone-like compounds as antituberculosis agents
TLDR
Four multicaulin and miltirone-like phenanthrene derivatives were synthesised and evaluated as antituber tuberculosis agents and the best antituberculosis activity was exhibited by 2-isopropylphenanthrene-3-ol.
Disassembly of polymeric nanoparticles with enzyme-triggered polymer unzipping: polyelectrolyte complexes vs. amphiphilic nanoassemblies.
TLDR
Hydrophilic and hydrophobic modification of the polymer was carried out for the formation of a polyelectrolyte complex and an amphiphilic nanoassembly, respectively, which offered distinct enzyme-triggered disassembly kinetics.
Synthesis, molecular docking, and antitumoral activity of alnustone-like compounds against estrogen receptor alpha-positive human breast cancer
TLDR
The protective and inhibitive roles of the synthesized alnustone-like compounds were related to their functional groups and to their binding mode of action on ER-a protein.
Total syntheses of multicaulins via oxidative photocyclization of stilbenes.
TLDR
Oxidative photocyclization of stilbene 16 with iodine facilitated the first total synthesis of 7-isopropyl-6-methoxy-1,2-dimethylphenanthrene, multicaulin, O-demethylmulticaulin.
Syntheses and antibacterial activities of 4 linear nonphenolic diarylheptanoids
TLDR
Four linear nonphenolic diarylheptanoids were synthesized and their antibacterial activities were studied, exhibiting different degrees of antimicrobial activity at concentrations between 20–100 μg/disc against the test organisms.
Synthesis of Two Natural Furan‐Cyclized Diarylheptanoids via 2‐Furaldehyde
Two natural diarylheptanoids, 2-benzyl-5-(2-phenylethyl)furan (1) and 2-methoxy-4-{[5-(2-phenylethyl)furan-2-yl]methyl}phenol (2), were synthesized starting from 2-furaldehyde. A Wittig reaction of
EVALUATION OF HPLC, PHYTOCHEMICAL, ANTICHOLINESTERASE AND ANTIOXIDANT PROFILES OF THE AERIAL PARTS OF ASPERULA TAURINA SUBSP. CAUCASICA
Amac: Bu calismada, Asperula taurina subsp. caucasica'nin toprak ustu kisimlarinin YBSK, fitokimyasal, antikolinesteraz ve antioksidan profillerinin degerlendirilmesi amaclanmistir. Gerec ve Yontem: