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Due to their unique properties, Anticancer dendrimer-based drugs have been displaying promising results in both in vitro and in vivo in the treatment of cancerous cells, as compared to the traditional polymers. In this report, two conjugates (G1+Pt and G2+Pt) of cisplatin [cis-diaminedichloroplatinum; (CDDP)] with two generations (G1, G2) of a biocompatible(More)
  • Hassan Namazi, Yousef Toomari Hamrahloo
  • 2011
INTRODUCTION In this work, the use of β-cyclodextrine (β-CD)-modified dendrimers as a nanocapsule with a biocompatible shell have studied. β-CD-modifieddendrimers have designed and synthesized to enhance the loading capacity of the final dendrimers with encapsulation properties. METHODS To achieve β-CD-modified dendrimers, first citric acid dendrimers(More)
A general synthetic route for the exclusive preparation of tetrasubstituted imidazoles, possessing benzylic methyl groups has been developed using $$\hbox {Sb}_{2}\hbox {O}_{3}$$ Sb 2 O 3 via solvent-free, one-pot reaction conditions. Detailed results from our investigation on the bromination of the benzylic methyl groups of imidazoles are described. The(More)
INTRODUCTION Peptide dendrimers build up from amino acids and they simulate to artificial proteins with globular architecture. These characteristics furnish peptide dendrimers with best biodegradability and biocompatibility in drug delivery systems. METHODS A barbell-like dendrimer from glutamic acid dimethyl ester-poly (ethylene glycol)-glutamic acid(More)
The regioselective C-2-O-acrylation and metacrylation of methyl 4,6-O-benzylidene-alpha-D-glucopyranoside and methyl 4,6-O-benzylidene-alpha-D-galactopyranoside through their corresponding organotin intermediates have been studied. Regioselectivity was achieved through the formation of a tin chelate of the 2,3-diols. Thus, methyl(More)
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