Hassan Namazi

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Due to their unique properties, Anticancer dendrimer-based drugs have been displaying promising results in both in vitro and in vivo in the treatment of cancerous cells, as compared to the traditional polymers. In this report, two conjugates (G1+Pt and G2+Pt) of cisplatin [cis-diaminedichloroplatinum; (CDDP)] with two generations (G1, G2) of a biocompatible(More)
Citric acid-polyethylene glycol-citric acid (CPEGC) triblock dendrimers as biocompatible compounds containing G(1), G(2) and G(3) were applied as the drug-delivery systems. Some of the small size molecules and drugs are trapped with the above-synthesized dendrimers. The guest molecules, which are hydrophobic when trapped into the suitable sites of(More)
The use of dendrimers as nano-sized excipients/vectors in biological and pharmaceutical systems is dependent on the investigation of their toxicological profiles in biological media. In this study, a series of mechanistic in vitro structure-associated cell toxicity evaluations was performed on the two generations of an anionic linear-globular dendrimer G1(More)
Dendritic micelles formed from amphiphilic dendritic ABA triblock copolymers based on organic linear poly(ethylene oxide) and inorganic dendritic block containing silicon atoms (OSC-D(Gn)-PEO-D(Gn)-CSO, n=1-3)(1) were evaluated as drug delivery vehicles for a drug in both lipophilic and hydrophilic forms. The physical parameters of the drug-incorporated(More)
INTRODUCTION In this work, the use of β-cyclodextrine (β-CD)-modified dendrimers as a nanocapsule with a biocompatible shell have studied. β-CD-modifieddendrimers have designed and synthesized to enhance the loading capacity of the final dendrimers with encapsulation properties. METHODS To achieve β-CD-modified dendrimers, first citric acid dendrimers(More)
INTRODUCTION Citric acid-polyethylene glycol-citric acid (CPEGC) triblock dendrimers can serve as potential delivery systems. METHODS In this investigation, CPEGC triblock dendrimers were synthesized and then imidazole groups were conjugated onto the surface of the G1, G2 and G3 of the obtained dendrimers. In order to study the type of the interactions(More)
Silver nanoparticles were synthesized in situ during the formation of physically crosslinked chitosan hydrogel beads using sodium tripolyphosphate as the crosslinker. The aim of the study was to investigate whether these nanocomposite beads have the potential to be used in drug delivery applications. The formation of silver nanoparticles (AgNPs) in the(More)
This paper deals with the preparation of antibacterial nanocomposite hydrogels through the combination of carboxy methyl cellulose (CMC), layered double hydroxides (LDH), and silver nanoparticles (AgNPs). CMC-LDH hydrogels were prepared by intercalating CMC into different LDHs. Then, Ag/CMC-LDH nanocomposite hydrogels were prepared through in situ formation(More)
PURPOSE A simple type of photoresponsive amphiphilic linear-dendritic diblock copolymer has been synthesized and investigated for its ability to act as a drug carrier. These structures contain hydrophilic polyethylene oxide monomethyl ether (PEOM) as hydrophilic block and carbosiloxane dendritic branches as hydrophobic block grafted by two and six Magneson(More)
Solution casting method was employed for preparing of carboxymethyl cellulose/layered double hydroxide (CMC-LDH) bionanocomposite films with LDH content ranged from 0 to 8 wt%. The synthesized nanocomposite films were characterized using FTIR, XRD, TEM and SEM analytical methods. XRD and TEM analysis revealed a partially exfoliated structure for(More)