Hassan Alizadeh

2Jerry Y Niederkorn
1Trivendra Tripathi
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PURPOSE To assess the expression of PD-L1 on human uveal melanomas and its potential to suppress T-cell function. METHODS A panel of primary and metastatic uveal melanoma cell lines was evaluated for PD-L1 expression by RT-PCR and flow cytometric analysis. Uveal melanoma-containing eyes were examined for PD-L1 expression by immunohistochemistry. PD-L1(More)
PURPOSE Acanthamoeba trophozoites express a mannose binding receptor that facilitates adhesion of trophozoites to mannosylated proteins on corneal epithelial cells. This study was undertaken to determine the role that mannose stimulation has in the amoeba's growth, secreted products, and ability to desquamate the corneal epithelium. METHODS Acanthamoeba(More)
Free-living amoebae of the Acanthamoeba species are the causative agent of Acanthamoeba keratitis (AK), a sight-threatening corneal infection that causes severe pain and a characteristic ring-shaped corneal infiltrate. Innate immune responses play an important role in resistance against AK. The aim of this study is to determine if Toll-like receptors (TLRs)(More)
This paper presents an application-specific intrusion detection framework in order to address the problem of detecting intrusions in individual applications when their traffic exhibits anomalies. The system is based on the assumption that authorized traffic analyzers have access to a trustworthy binding between network traffic and the source application(More)
PURPOSE Instillation of sterile 1.0 microM latex beads into the central corneal epithelium renders Chinese hamsters resistant to corneal infection with Acanthamoeba castellanii. By contrast, activation of the adaptive immune response by subcutaneous immunization with A. castellanii antigens fails to protect against Acanthamoeba keratitis. This study was(More)
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