Hassan Akbari

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We fabricated a targeted delivery system for doxorubicin (Dox) using β-1,3-glucan (Glu) as a carrier and decorated by trastuzumab antibody having the status of targeting agent against Her2+ breast tumors. Glu-Dox conjugates were also functionalized with polyethylenimine (PEI) intended for increasing specific cellular uptake of prepared nanoparticles. The(More)
Satureja spicigera (Lamiaceae) grows wildly in Northwest of Iran. In this study, bioassay-guided isolation and identification of the main compounds has been reported using various chromatographic methods and comparison of their spectral data with those reported in the literature. Brine shrimp lethality and four cancerous cell lines HT29/219, Caco(2),(More)
Image segmentation with clustering approach is widely used in biomedical application. Fuzzy c-means (FCM) clustering is able to preserve the information between tissues in image, but not taking spatial information into account, makes segmentation results of the standard FCM sensitive to noise. To overcome the above shortcoming, a modified FCM algorithm for(More)
In this paper, we introduce a novel approach based on Tucker Decomposition and quasi-periodic nature of ECG signal for fetal ECG extraction from abdominal ECG mixture. We adapt variable periodicity constraint of the ECG components to main objective function of the Tucker Decomposition and shape it to matrix form in order to simply optimize the objective(More)
Most of the applied and interesting problems in industry and real world are difficult to solve. These problems are often NP-hard and the problem in this paper is strongly NP-hard. Approximation and metaheuristic algorithms are used to find a solution to these problems. In this paper we have used a polynomial time approximation algorithm, this algorithm is a(More)
BACKGROUND/AIMS Gastric cancer (GC) is the second leading cause of cancer-related deaths worldwide and is the most frequent cancer in Iran. Epstein-Barr virus (EBV) has been shown to be associated with gastric cancer. The present study was carried out to investigate the prevalence of Epstein-Barr virus (EBV) associated gastric cancer among Iranian patients.(More)
OBJECTIVE Pre-exposure of rats to normobaric hyperoxia (O2 ≥ 95%) may induce late preconditioning against renal ischemia-reperfusion (IR) injury. In this study we investigated probable mechanisms of IR injury such as the role of reactive oxygen species (ROS), renal antioxidant agents, and heat shock proteins (HSP) 32 and 70 during delayed(More)
Lung exposure to sulfur mustard (SM) results in pulmonary complications, which is the main cause of long-term disability and morbidity. Up to now, the precise mechanisms of SM-induced lung complications has not been identified. The aim of this study was to evaluate apoptosis in the lung tissue of SM-exposed individuals. The study was performed on archived(More)
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