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MOTIVATION The knowledge of protein structure is not sufficient for understanding and controlling its function. Function is a dynamic property. Although protein structural information has been rapidly accumulating in databases, little effort has been invested to date toward systematically characterizing protein dynamics. The recent success of analytical(More)
Protein function is a dynamic property closely related to the conformational mechanisms of protein structure in its physiological environment. To understand and control the function of target proteins, it becomes increasingly important to develop methods and tools for predicting collective motions at the molecular level. In this article, we review(More)
An assessment of the equilibrium dynamics of biomolecular systems, and in particular their most cooperative fluctuations accessible under native state conditions, is a first step towards understanding molecular mechanisms relevant to biological function. We present a web-based system, oGNM that enables users to calculate online the shape and dispersion of(More)
that emerges as a result of convergence of telecommunication and geoinformatics, and encompasses two important components: location-based computing and services. It provides the fundamental computing and communication infrastructure in computing on the one hand, and supports the set of technologies and data to process application-specific request in(More)
In this paper, a discussion of employing Global Positioning System (GPS) and geographic information system (GIS) technologies for packet routing strategies in ad hoc mobile wireless networks is presented. Mobile network architectures and existing packet routing schemes are briefly discussed to illustrate how GPS and GIS techniques can be beneficially(More)