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Nonsense-mediated mRNA decay in human cells: mechanistic insights, functions beyond quality control and the double-life of NMD factors
Nonsense-mediated decay is well known by the lucid definition of being a RNA surveillance mechanism that ensures the speedy degradation of mRNAs containing premature translation termination codons.Expand
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Autoregulation of the nonsense-mediated mRNA decay pathway in human cells.
Nonsense-mediated mRNA decay (NMD) is traditionally portrayed as a quality-control mechanism that degrades mRNAs with truncated open reading frames (ORFs). However, it is meanwhile clear that NMDExpand
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Transcriptome response to heavy metal stress in Drosophila reveals a new zinc transporter that confers resistance to zinc
All organisms are confronted with external variations in trace element abundance. To elucidate the mechanisms that maintain metal homeostasis and protect against heavy metal stress, we haveExpand
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A Family Knockout of All Four Drosophila Metallothioneins Reveals a Central Role in Copper Homeostasis and Detoxification
ABSTRACT Metallothioneins are ubiquitous, small, cysteine-rich proteins with the ability to bind heavy metals. In spite of their biochemical characterization, their in vivo function remains elusive.Expand
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Knockout of ‘metal‐responsive transcription factor’ MTF‐1 in Drosophila by homologous recombination reveals its central role in heavy metal homeostasis
‘Metal‐responsive transcription factor‐1’ (MTF‐1), a zinc finger protein, is conserved from mammals to insects. In the mouse, it activates metallothionein genes and other target genes in response toExpand
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Metal-responsive transcription factor (MTF-1) handles both extremes, copper load and copper starvation, by activating different genes.
From insects to mammals, metallothionein genes are induced in response to heavy metal load by the transcription factor MTF-1, which binds to short DNA sequence motifs, termed metal response elementsExpand
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FOXO3a Regulates Glycolysis via Transcriptional Control of Tumor Suppressor TSC1*
Akt signal transduction induces coordinated increases in glycolysis and apoptosis resistance in a broad spectrum of cancers. Downstream of Akt, the FoxO transcription factors regulate apoptosis viaExpand
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Requirement for ribosomal protein S6 kinase 1 to mediate glycolysis and apoptosis resistance induced by Pten deficiency
Pten inactivation promotes cell survival in leukemia cells by activating glycolytic metabolism. We found that targeting ribosomal protein S6 kinase 1 (S6K1) in Pten-deficient cells suppressedExpand
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tRNASec is transcribed by RNA polymerase II in Trypanosoma brucei but not in humans
Nuclear-encoded tRNAs are universally transcribed by RNA polymerase III (Pol-III) and contain intragenic promoters. Transcription of vertebrate tRNASec however requires extragenic promoters similarExpand
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FOXO 3 a REGULATES GLYCOLYSIS VIA TRANSCRIPTIONAL CONTROL OF TUMOR SUPPRESSOR TSC 1
Akt signal transduction induces coordinated increases in glycolysis and apoptosis resistance in a broad spectrum of cancers. Downstream of Akt, the FoxO transcription factors regulate apoptosis viaExpand
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