Hashim Uddin Ahmed

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A deformable registration method is described that enables automatic alignment of magnetic resonance (MR) and 3D transrectal ultrasound (TRUS) images of the prostate gland. The method employs a novel "model-to-image" registration approach in which a deformable model of the gland surface, derived from an MR image, is registered automatically to a TRUS volume(More)
There is growing clinical demand for image registration techniques that allow multimodal data fusion for accurate targeting of needle biopsy and ablative prostate cancer treatments. However, during procedures where transrectal ultrasound (TRUS) guidance is used, substantial gland deformation can occur due to TRUS probe pressure. In this paper, the ability(More)
BACKGROUND Radical whole-gland therapy can lead to significant genitourinary and rectal side-effects for men with localised prostate cancer. We report on whether selective focal ablation of unifocal and multifocal cancer lesions can reduce this treatment burden. METHODS Men aged 45-80 years were eligible for this prospective development study if they had(More)
CONTEXT The incidence of localised prostate cancer is increasing worldwide. In light of recent evidence, current, radical, whole-gland treatments for organ-confined disease have being questioned with respect to their side effects, cancer control, and cost. Focal therapy may be an effective alternative strategy. OBJECTIVE To systematically review the(More)
A method is described for registering preoperative magnetic resonance (MR) to intraoperative transrectal ultrasound (TRUS) images of the prostate gland. A statistical motion model (SMM) of the prostate is first built using training data provided by biomechanical simulations of the motion of a patient-specific finite element model, derived from a(More)
OBJECTIVE To evaluate the feasibility of using computer-assisted, deformable image registration software to enable three-dimensional (3D), multi-parametric (mp) magnetic resonance imaging (MRI)-derived information on tumour location and extent, to inform the planning and conduct of focal high-intensity focused ultrasound (HIFU) therapy. PATIENTS AND(More)
A method is described for generating a patient-specific, statistical motion model (SMM) of the prostate gland. Finite element analysis (FEA) is used to simulate the motion of the gland using an ultrasound-based 3D FE model over a range of plausible boundary conditions and soft-tissue properties. By applying principal component analysis to the displacements(More)
BACKGROUND The use of minimally invasive ablative therapies in localised prostate cancer offer potential for a middle ground between active surveillance and radical therapy. METHODS An analysis of men with organ-confined prostate cancer treated with transrectal whole-gland HIFU (Sonablate 500) between 1 February 2005 and 15 May 2007 was carried out in two(More)
PURPOSE To assess the performance of multiparametric magnetic resonance imaging (mp-MRI) in patients with previous negative transrectal ultrasound (TRUS) guided prostate biopsy. MATERIALS AND METHODS Fifty-four patients with at least 1 previous negative TRUS prostate biopsy underwent mp-MRI in the form of T2-weighted, diffusion-weighted, and dynamic(More)