Haruo Toda

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Disrupted-in-schizophrenia-1 (DISC1) is one of major susceptibility factors for a wide range of mental illnesses, including schizophrenia, bipolar disorder, major depression and autism spectrum conditions. DISC1 is located in several subcellular domains, such as the centrosome and the nucleus, and interacts with various proteins, including NudE-like(More)
The effects of watching video movies on autonomic functions were estimated by measuring changes in pupillary and cardiovascular parameters in 10 senior subjects. The subjects looked at a series of video images (with accompanied sounds) taken during the execution of motor vehicles. The images were rear-projected on a large screen for 15 min. Pupil diameter(More)
Electrocorticogram (ECoG) is a well-balanced methodology for stably mapping brain surface local field potentials (LFPs) over a wide cortical region with high signal fidelity and minimal invasiveness to the brain tissue. To directly compare surface ECoG signals with intracortical neuronal activity immediately underneath, we fabricated a flexible multichannel(More)
Ocular convergence and lens accomodation were evoked by microstimulation in the lateral suprasylvian area (LS cortex) in the parieto-occipital cortex in the cat. Electrolytic lesions in LS cortex reduced the amplitude and velocity of ocular convergence. Neurons in LS cortex discharged in relation to ocular convergence and/or lens accommodation. These(More)
Slow disjunctive eye movement similar to ocular convergence was evoked by microstimulation in parts of the lateral suprasylvian area (LSA) in alert cats. A tungsten-in-glass microelectrode was used for stimulation, and eye movement was monitored using the magnetic search coil method. The velocity-versus-amplitude relationship of disjunctive eye movement(More)
The lateral suprasylvian (LS) area, an extrastriate visual area in the cat, has been suggested to play an important role in processing motion in 3-dimensional visual space. In addition, the LS area is related to all three components of the ocular near response, i.e. lens accommodation, pupillary constriction, and ocular convergence: microstimulation in this(More)
Neuronal spike discharges were recorded from the lateral suprasylvian (LS) area while ocular convergence was elicited in five alert cats. Ocular convergence was elicited by presenting a visual target moving in depth. Cats were rewarded for convergence eye movement. In 9 out of 426 cells sampled in the caudal postero-medial LS area, the number of spikes was(More)
Taka-amylase A (1,4-alpha-D-glucan glucanohydrolase, EC, which contains a single asparagine-linked oligosaccharide unit, was digested with almond glycopeptidase immobilized on Sepharose 6B at 20 degrees C for 4 h. A maximum of 10% of the parent protein was isolated as apoprotein by column chromatography on Con-A Sepharose. The characteristics of(More)
Projections of the pupillo-constrictor area in the postero-medial lateral suprasylvian area (PMLS) to that in cortical area 20 was studied using electrophysiological and anatomical methods. Cats were injected with wheatgerm agglutinin-conjugated horseradish peroxidase in the latter area, which was located by intracortical stimulation. Retrogradely labeled(More)