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Although hydroxyapatite (HAP) and tricalcium phosphate (TCP) are currently used as bone graft substitutes or coatings on metallic prostheses because of their excellent biocompatibility and osteoconductivity, they do not stimulate bone formation or inhibit bone resorption. Zinc, an essential trace element in many animals, has a direct specific proliferative(More)
Zinc is an essential trace element that has stimulatory effects on bone formation. Recently, we developed zinc-releasing calcium phosphate ceramics in order to add the pharmacologic effect of zinc to calcium phosphate ceramics. In our previous study, we showed that the optimum zinc content for promoting bone formation was 0.316 wt %. Therefore a zinc(More)
BACKGROUND Tapered femoral stems have been shown to produce less thigh pain and stress shielding than other cement-less stem designs. The purpose of this study was to examine the performance of this type of femoral stem in Japanese patients. METHODS A series of 40 total hip arthroplasties with a Synergy tapered femoral component were performed in 33(More)
BACKGROUND Uncemented fixation of components in joint arthroplasty is achieved primarily through de novo bone formation at the bone-implant interface and establishment of a biological and mechanical interlock. In order to enhance bone-implant integration osteoconductive coatings and the methods of application thereof are continuously being developed and(More)
Using zinc-containing tricalcium phosphate (ZnTCP) as the zinc carrier for zinc-releasing calcium phosphate ceramic implants promoted bone formation around the implants. Because no quantitative information was available on the equilibrium solubility and resorbability of ZnTCP, in vitro equilibrium solubility and in vivo resorbability of ZnTCP were(More)
Synergy stems are tapered stems featuring a proximal porous coating, grid blasting below the proximal third to the distal end. This study included 41 patients (50 hips) who underwent total hip arthroplasty with follow-ups for 10 years or more. No stem reimplantations were performed. Spot welds were observed in the distal stem in Gruen zones 3 and 5 in 35(More)
We report long-term results of the first clinical trial of hydroxyapatite-coated total hip arthroplasty conducted in Japan. The hemispherical cup and the straight-tapered stem were made of titanium alloy with a grit-blasted, hydroxyapatite-coated surface. The surface roughness before and after hydroxyapatite coating was 1.4 microm and 3.4 microm,(More)
It has been suggested brain serotonin (5HT) plays a role in regulation of the hypothalamic-pituitary-adrenal system, although none of the experimental approaches so far reported has produced unequivocal results, mainly on account of the static tissue 5HT level or the known effects of drugs being employed in interpretation of their data. The present study in(More)
FluorEver is one kind of fluoride releasing composite resin. The first aim of this study was to investigate the amount of fluoride released from FluorEver. The second aim of this study was to determine the uptake of fluoride with bovine enamel, which was immersed in distilled water for 28 days in contact with FluorEver, compared with Fuji Ionomer cement(More)
BACKGROUND The Harris-Galante total hip arthroplasty (THA) is a first-generation cementless THA with a porous coating for biological fixation of the implant. Many studies report excellent long-term results for the acetabular cup, but few long-term studies exist for the femoral stem because of relatively poor short-term and midterm results. Here we present(More)