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OBJECT Recently, intraoperative mapping has disclosed that, in addition to the classic language centers (that is, the Broca and Wernicke centers), other cortical regions may also play an important role in language organization. In the prefrontal cortex, although the lateral superior frontal gyrus (LSFG) could have language-related functions, there are no(More)
Axolotls (Ambystoma mexicanum) have the ability to regenerate amputated limbs throughout their life span. In the present study, we attempted to elucidate how axolotls can specify limb type correctly during the regeneration process. We misexpressed Tbx5 in regenerating hindlimb blastema, and consequently a forelimb-like hindlimb regenerated from the hindlimb(More)
Diabetic nephropathy is a major microvascular complication in long-standing diabetic patients who eventually undergo renal dialysis or transplantation. To prevent development of this disease and to improve advanced kidney injury, effective therapies directed toward the key molecular target are required. In this study, we examined whether inhibition of the(More)
The receptor for advanced glycation end products (RAGE) is a cell surface multiligand receptor of the immunoglobulin superfamily, which participates in physiological and pathological processes such as neuronal development, diabetes, inflammation, neurodegenerative disorders, and cancer. A novel splice variant of RAGE-endogenous secretory decoy form (esRAGE)(More)
We studied the proliferation of pituitary corticotrophs quantitatively by labeling the proliferating cells with bromodeoxyuridine (BrdU) and carrying out immunocytochemistry for ACTH in rat fetuses at 19.5 days of gestation. In addition to labeling proliferating cells with a single injection of BrdU, we used double BrdU administrations at 9:00 and 19:00 for(More)
Proliferation of somatotrophs and mammotrophs in the rat pituitary during late fetal and postnatal periods up to 4 weeks after birth was quantitatively studied with the double immunostaining of bromodeoxyuridine and the hormones produced by them. Somatotrophs were first detected in 18.5-day fetuses and rapidly increased in number throughout the periods(More)
Pituitary glands from rat fetuses (gestational age 17.5-21.5 days) and rat pups (3, 7, 10, 14, 28 days old) were labeled with bromodeoxyuridine (BrdU) 2 h prior to sacrifice and embedded in paraffin. Sections were consecutively immunostained with anti-BrdU and anti-rat TSH. The number of cells stained with anti-BrdU, anti-rTSH, or both of them were counted.(More)
The peritoneal surface of the golden hamster diaphragm was examined for closed lymphatic stomata by scanning electron microscopy (SEM) and serial sectioning. Closed stomata were absent on SEM but present on serial sectioning. Some closed stomata in the serial sections were reconstructed using a computerized image analysis system. They were less than 10(More)
Numerous circular fenestrations or pores were present in the pericardium of the rat, golden hamster, and mouse. The pericardial pores were most numerous in the mouse. They were usually less than 50 micron in diameter and situated in a meshwork formed by thick, wavy bundles of collagen fibers and thin, straight, elastic fibers. These pores directly connected(More)
Development of thyrotrophs in the rat pituitary at 3, 7 and 10 days after birth was quantitatively studied by labelling the proliferating cells with bromodeoxyuridine (BrdU) and with the proliferating cell nuclear antigen (PCNA), and the immunostaining of thyrotrophs was applied to the same tissue section. Double administration of BrdU at 9:00 h and 19:00(More)