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Signaling networks that regulate muscle development: Lessons from zebrafish
Locomotion mediated by skeletal muscle provides a basis for the behavioral repertoire of most animals. Embryological and genetic studies of mouse, bird, fish and frog embryos are providing insightsExpand
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Heterochronic Shift in Hox-Mediated Activation of Sonic hedgehog Leads to Morphological Changes during Fin Development
We explored the molecular mechanisms of morphological transformations of vertebrate paired fin/limb evolution by comparative gene expression profiling and functional analyses. In this study, weExpand
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Smarcd3 Regulates the Timing of Zebrafish Myogenesis Onset*
A cascade of signaling events triggers myogenesis in vertebrates. Although studies of zebrafish indicate that fibroblast growth factor (Fgf), Hedgehog (Hh), and the T-box transcription factors, NoExpand
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Lbx2 regulates formation of myofibrils
BackgroundSkeletal muscle differentiation requires assembly of contractile proteins into organized myofibrils. The Drosophila ladybird homeobox gene (lad) functions in founder cells of the segmentalExpand
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Hhip regulates zebrafish muscle development by both sequestering Hedgehog and modulating localization of Smoothened.
Sharp borders between cells with different developmental fates are important for patterning of invertebrates, but are not well understood in vertebrates. Zebrafish slow muscle cells develop fromExpand
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Different Requirement for Wnt/β-Catenin Signaling in Limb Regeneration of Larval and Adult Xenopus
Background In limb regeneration of amphibians, the early steps leading to blastema formation are critical for the success of regeneration, and the initiation of regeneration in an adult limb requiresExpand
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Resources and transgenesis techniques for functional genomics in Xenopus
Recent developments in genomic resources and high‐throughput transgenesis techniques have allowed Xenopus to ‘metamorphose’ from a classic model for embryology to a leading‐edge experimental systemExpand
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Photoporation of Biomolecules into Single Cells in Living Vertebrate Embryos Induced by a Femtosecond Laser Amplifier
Introduction of biomolecules into cells in living animals is one of the most important techniques in molecular and developmental biology research, and has potentially broad biomedical implications.Expand
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Comparative genomics-based identification and analysis of cis-regulatory elements.
Identification of cis-regulatory elements, such as enhancers and promoters, is very important not only for analysis of gene regulatory networks but also as a tool for targeted gene expressionExpand
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A Novel Cysteine Knot Protein for Enhancing Sperm Motility That Might Facilitate the Evolution of Internal Fertilization in Amphibians
Internal fertilization ensures successful reproduction of tetrapod vertebrates on land, although how this mode of reproduction evolved is unknown. Here, we identified a novel gene encoding spermExpand
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