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Role of Lmx1b and Wnt1 in mesencephalon and metencephalon development.
TLDR
The relationship among isthmus related genes is examined, the mechanism of the formation and maintenance of isthmic organizing activity is discussed, and the role of Wnt1 is considered. Expand
Interaction between Otx2 and Gbx2 defines the organizing center for the optic tectum
TLDR
It is suggested that interaction between Otx2 and Gbx2 determines the site of Fgf8 expression and the posterior limit of the tectum. Expand
The Fgf8 signal causes cerebellar differentiation by activating the Ras-ERK signaling pathway
TLDR
The results indicate that the presumptive metencephalon receives a strong Fgf8 signal that activates the Ras-ERK pathway and differentiates into the cerebellum. Expand
Repulsive Guidance Molecule Plays Multiple Roles in Neuronal Differentiation and Axon Guidance
TLDR
This work provides the first evidence for a role for RGMs in axon guidance in vivo and suggests that RGMa exerts multiple functions during neural development. Expand
R-spondin3 is required for mouse placental development.
TLDR
A critical role is suggested for Rspo3 in the interaction between chorion and allantois in labyrinthine development in mice bearing a mutant RSpo3 allele. Expand
A Role for Gradient en Expression in Positional Specification on the Optic Tectum
TLDR
It is reported that scattered en expression, caused by retroviral gene transfer, perturbed the retinotopic order and suggest that gradient en expression defines the positional identity of the tectum along the rostrocaudal axis. Expand
How does Fgf signaling from the isthmic organizer induce midbrain and cerebellum development?
TLDR
How the isthmus instructs the differentiation of the midbrain versus cerebellum is discussed, and Fgf8 is shown to play a pivotal role in isthmic organizer activity. Expand
Isthmus organizer for midbrain and hindbrain development
TLDR
A strong Fgf8 signal activates the Ras-ERK signaling pathway, which in turn activates Irx2 in a rostrodorsal part of the hindbrain, and forces this tissue to differentiate into cerebellum. Expand
Actin bundles on the right side in the caudal part of the heart tube play a role in dextro-looping in the embryonic chick heart
TLDR
It is suggested that actin bundles on the right side of the caudal part of a heart tube generate tension and cause dextro-looping. Expand
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